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Enzyme List for CamKII acting as a Product

Entries are grouped according to Pathway Number and they are alternately color coded using  and   color.
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  Enzyme Molecule /

 Enzyme Activity		Accession Name / 
Accession No.		Pathway Name / 
Pathway No.		Km
(uM)		kcat
(s^-1)		Ratio
(k2/k3)		Enzyme TypeReagents
1 PP1-active  /
Deph-thr286		fig3_CaMKII

Accession No. 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. 12
    		• 5.099070.354explicit E-S complexSubstrate: 
  • CaMKII-thr286*-C
    aM
    Product : 
    CaMKII-CaM
    • 2 PP1-active  /
    Deph-thr305    		fig3_CaMKII

    Accession No. 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. 12
    		• 5.099070.354explicit E-S complexSubstrate: 
    CaMKII***
    Product : 
    CaMKII-thr286
    3 PP1-active  /
    Deph-thr306    		fig3_CaMKII

    Accession No. 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. 12
    		• 5.099070.354explicit E-S complexSubstrate: 
    CaMK-thr306
    Product : 
    CaMKII
    4 PP1-active  /
    Deph_thr286b    		fig3_CaMKII

    Accession No. 2
  • Shared_Object_
    fig3_CaMKII
    Pathway No. 12
    		• 5.099070.354explicit E-S complexSubstrate: 
    CaMKII-thr286
    Product : 
    CaMKII
    5 tot_CaM_CaMKII  /
    CaM_act_305    		fig3_CaMKII

    Accession No. 2    		CaMKII

    Pathway No. 13    		0.0000027056364explicit E-S complexSubstrate: 
    CaMKII-thr286
    Product : 
    CaMKII***
    6 tot_CaM_CaMKII  /
    CaM_act_286    		fig3_CaMKII

    Accession No. 2    		CaMKII

    Pathway No. 13    		0.000002705630.54explicit E-S complexSubstrate: 
    CaMKII-CaM
    Product : 
  • CaMKII-thr286*-C
    aM
    • 7 
  • tot_autonomous_
    CaMKII      /
    auton_305
    		• fig3_CaMKII

    Accession No. 2    		CaMKII

    Pathway No. 13    		0.0000041666764explicit E-S complexSubstrate: 
    CaMKII-thr286
    Product : 
    CaMKII***
    8 
  • tot_autonomous_
    CaMKII      /
    auton_286
    		• fig3_CaMKII

    Accession No. 2    		CaMKII

    Pathway No. 13    		0.000004166670.54explicit E-S complexSubstrate: 
    CaMKII-CaM
    Product : 
  • CaMKII-thr286*-C
    aM
    • 9 PP1-active  /
    Deph-thr286    		fig4_synapse

    Accession No. 3
  • Shared_Object_
    fig4_synapse
    Pathway No. 19
    		• 5.099070.354explicit E-S complexSubstrate: 
  • CaMKII-thr286*-C
    aM
    Product : 
    CaMKII-CaM
    • 10 PP1-active  /
    Deph-thr305    		fig4_synapse

    Accession No. 3
  • Shared_Object_
    fig4_synapse
    Pathway No. 19
    		• 5.099070.354explicit E-S complexSubstrate: 
    CaMKII***
    Product : 
    CaMKII-thr286
    11 PP1-active  /
    Deph-thr306    		fig4_synapse

    Accession No. 3
  • Shared_Object_
    fig4_synapse
    Pathway No. 19
    		• 5.099070.354explicit E-S complexSubstrate: 
    CaMK-thr306
    Product : 
    CaMKII
    12 PP1-active  /
    Deph_thr286b    		fig4_synapse

    Accession No. 3
  • Shared_Object_
    fig4_synapse
    Pathway No. 19
    		• 5.099070.354explicit E-S complexSubstrate: 
    CaMKII-thr286
    Product : 
    CaMKII
    13 tot_CaM_CaMKII  /
    CaM_act_305    		fig4_synapse

    Accession No. 3    		CaMKII

    Pathway No. 26    		0.0000027056364explicit E-S complexSubstrate: 
    CaMKII-thr286
    Product : 
    CaMKII***
    14 tot_CaM_CaMKII  /
    CaM_act_286    		fig4_synapse

    Accession No. 3    		CaMKII

    Pathway No. 26    		0.000002705630.54explicit E-S complexSubstrate: 
    CaMKII-CaM
    Product : 
  • CaMKII-thr286*-C
    aM
    • 15 
  • tot_autonomous_
    CaMKII      /
    auton_305
    		• fig4_synapse

    Accession No. 3    		CaMKII

    Pathway No. 26    		0.0000041666764explicit E-S complexSubstrate: 
    CaMKII-thr286
    Product : 
    CaMKII***
    16 
  • tot_autonomous_
    CaMKII      /
    auton_286
    		• fig4_synapse

    Accession No. 3    		CaMKII

    Pathway No. 26    		0.000004166670.54explicit E-S complexSubstrate: 
    CaMKII-CaM
    Product : 
  • CaMKII-thr286*-C
    aM
    • 17 PP1-active  /
    Deph-thr286
  • Synaptic_
    Network
    Accession No. 16
  • Shared_Object_
    Synaptic_
    Network
    Pathway No. 70
    		• 5.099070.354explicit E-S complexSubstrate: 
  • CaMKII-thr286*-C
    aM
    Product : 
    CaMKII-CaM
    •   The rates are from Stralfors et al Eur J Biochem 149 295-303 giving Vmax = 5.7 umol/min giving k3 = 3.5/sec and k2 = 14. Foulkes et al Eur J Biochem 132 309-313 1983 give Km = 5.1 uM so k1 becomes 5.72e-6 Simonelli 1984 (Grad Thesis, CUNY) showed that other substrates are about 1/10 rate of phosphorylase a, so we reduce k1,k2,k3 by 10 to 5.72e-7, 1.4, 0.35. This gives the final Km of 5.1, and Vmax of 0.35/sec.
    18 PP1-active  /
    Deph-thr305
  • Synaptic_
    Network
    Accession No. 16
  • Shared_Object_
    Synaptic_
    Network
    Pathway No. 70
    		• 5.099070.354explicit E-S complexSubstrate: 
    CaMKII***
    Product : 
    CaMKII-thr286
      Dephosphorylation kinetics are assumed to be the same for all phosphorylation sites on CaMKII. The rates are from Stralfors et al Eur J Biochem 149 295-303 giving Vmax = 5.7 umol/min giving k3 = 3.5/sec and k2 = 14. Foulkes et al Eur J Biochem 132 309-313 1983 give Km = 5.1 uM so k1 becomes 5.72e-6 Simonelli 1984 (Grad Thesis, CUNY) showed that other substrates are about 1/10 rate of phosphorylase a, so we reduce k1,k2,k3 by 10 to 5.72e-7, 1.4, 0.35. This gives the final Km of 5.1, and Vmax of 0.35/sec.
    19 PP1-active  /
    Deph-thr306
  • Synaptic_
    Network
    Accession No. 16
  • Shared_Object_
    Synaptic_
    Network
    Pathway No. 70
    		• 5.099070.354explicit E-S complexSubstrate: 
    CaMK-thr306
    Product : 
    CaMKII
      Dephosphorylation kinetics are assumed to be the same for all phosphorylation sites on CaMKII. The rates are from Stralfors et al Eur J Biochem 149 295-303 giving Vmax = 5.7 umol/min giving k3 = 3.5/sec and k2 = 14. Foulkes et al Eur J Biochem 132 309-313 1983 give Km = 5.1 uM so k1 becomes 5.72e-6 Simonelli 1984 (Grad Thesis, CUNY) showed that other substrates are about 1/10 rate of phosphorylase a, so we reduce k1,k2,k3 by 10 to 5.72e-7, 1.4, 0.35. This gives the final Km of 5.1, and Vmax of 0.35/sec.
    20 PP1-active  /
    Deph_thr286b
  • Synaptic_
    Network
    Accession No. 16
  • Shared_Object_
    Synaptic_
    Network
    Pathway No. 70
    		• 5.099070.354explicit E-S complexSubstrate: 
    CaMKII-thr286
    Product : 
    CaMKII
      Rates are assumed to be the same for all phosphorylation sites on CaMKII. The rates are from Stralfors et al Eur J Biochem 149 295-303 giving Vmax = 5.7 umol/min giving k3 = 3.5/sec and k2 = 14. Foulkes et al Eur J Biochem 132 309-313 1983 give Km = 5.1 uM so k1 becomes 5.72e-6 Simonelli 1984 (Grad Thesis, CUNY) showed that other substrates are about 1/10 rate of phosphorylase a, so we reduce k1,k2,k3 by 10 to 5.72e-7, 1.4, 0.35. This gives the final Km of 5.1, and Vmax of 0.35/sec.
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