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Molecule Parameter List for PLC-Ca | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | fig2_egfr | 1 | Network |
Shared_Object_fig2_egfr, PKC, PLA2,
PLCbeta, Gq, MAPK,
Ras, EGFR, Sos,
PLC_g, CaRegulation | This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here. |
PLC-Ca acting as a Molecule in fig2_egfr Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | PLC-Ca | fig2_egfr
Accession No. : 1 | PLCbeta
Pathway No. : 4 | 0 | 1000 | No | | |
PLC-Ca acting as an Enzyme in fig2_egfr Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PLC-Ca /
PLC-Ca
| fig2_egfr
Accession No. : 1 | PLCbeta
Pathway No. : 4 | 19.8413 | 10 | 4 | explicit E-S complex | Substrate
PIP2
Product
DAG
IP3
|
PLC-Ca acting as a Substrate in a reaction in fig2_egfr Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | Act-PLC-by-Gq | fig2_egfr
Accession No. : 1 | PLCbeta
Pathway No. : 4 | 25.2
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.0397(uM) | - | Substrate
G*GTP
PLC-Ca
Product
PLC-Ca-Gq
|
PLC-Ca acting as a Product in a reaction in fig2_egfr Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | Act-PLC-Ca | fig2_egfr
Accession No. : 1 | PLCbeta
Pathway No. : 4 | 3
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.3333(uM) | - | Substrate
Ca
PLC
Product
PLC-Ca
| | 2 | Inact-PLC-Gq | fig2_egfr
Accession No. : 1 | PLCbeta
Pathway No. : 4 | 0.0133
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate
PLC-Ca-Gq
Product
G*GDP
PLC-Ca
|
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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