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Molecule Parameter List for inact-GEF

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

inact-GEF participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	2	0	2	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig2_egfr	1	Network	Shared_Object_fig2_egfr,  PKC,  PLA2,   PLCbeta,  Gq,  MAPK,   Ras,  EGFR,  Sos,   PLC_g,  CaRegulation
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here.

inact-GEF acting as a Molecule in  fig2_egfr Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
inact-GEF	fig2_egfr Accession No. : 1	Ras Pathway No. : 7	0.1	1000	No

inact-GEF acting as a Substrate for an Enzyme in  fig2_egfr Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PKC-active  / PKC-act-GEF	fig2_egfr Accession No. : 1	Shared_Object_ fig2_egfr Pathway No. : 1	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*
2	PKA-active  / PKA-phosph-GEF	fig2_egfr Accession No. : 1	Shared_Object_ fig2_egfr Pathway No. : 1	7.5	9	4	explicit E-S complex	Substrate inact-GEF Product inact-GEF*

inact-GEF acting as a Substrate in a reaction in  fig2_egfr Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	bg-act-GEF	fig2_egfr Accession No. : 1	Ras Pathway No. : 7	6 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.1667(uM)	-	Substrate BetaGamma inact-GEF Product GEF-Gprot-bg
2	CaM-bind-GEF	fig2_egfr Accession No. : 1	Ras Pathway No. : 7	60 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.0167(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF

inact-GEF acting as a Product in a reaction in  fig2_egfr Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	dephosph-GEF	fig2_egfr Accession No. : 1	Ras Pathway No. : 7	1 (s^-1)	0 (s^-1)	-	-	Substrate GEF* Product inact-GEF
2	dephosph-inact-G EF*	fig2_egfr Accession No. : 1	Ras Pathway No. : 7	1 (s^-1)	0 (s^-1)	-	-	Substrate inact-GEF* Product inact-GEF