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Molecule Parameter List for GAP | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | | fig2_egfr | 1 | Network |
Shared_Object_fig2_egfr, PKC, PLA2,
PLCbeta, Gq, MAPK,
Ras, EGFR, Sos,
PLC_g, CaRegulation | This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here. |
GAP acting as a Molecule in fig2_egfr Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | GAP | fig2_egfr
Accession No. : 1 | Ras
Pathway No. : 7 | 0.002 | 1000 | No | | |
GAP acting as an Enzyme in fig2_egfr Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | GAP /
GAP-inact-ras
| fig2_egfr
Accession No. : 1 | Ras
Pathway No. : 7 | 1.0104 | 10 | 100 | explicit E-S complex | Substrate
GTP-Ras
Product
GDP-Ras
|
GAP acting as a Substrate for an Enzyme in fig2_egfr Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | PKC-active /
PKC-inact-GAP | fig2_egfr
Accession No. : 1 | Shared_Object_
fig2_egfr
Pathway No. : 1 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate
GAP
Product
GAP*
|
GAP acting as a Product in a reaction in fig2_egfr Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | dephosph-GAP | fig2_egfr
Accession No. : 1 | Ras
Pathway No. : 7 | 0.1
(s^-1) | 0
(s^-1) | - | - | Substrate
GAP*
Product
GAP
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| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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