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Molecule Parameter List for GAP | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| GAP participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 1 | 1 | 0 | 0 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| fig2_egfr | 1 | Network | Shared_Object_fig2_egfr, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, EGFR, Sos, PLC_g, CaRegulation |
| This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here. | |||
GAP acting as a Molecule in fig2_egfr Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| GAP | fig2_egfr Accession No. : 1 | Ras Pathway No. : 7 | 0.002 | 1000 | No | |
GAP acting as an Enzyme in fig2_egfr Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| GAP / GAP-inact-ras | fig2_egfr Accession No. : 1 | Ras Pathway No. : 7 | 1.0104 | 10 | 100 | explicit E-S complex | Substrate GTP-Ras Product GDP-Ras |
GAP acting as a Substrate for an Enzyme in fig2_egfr Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
| PKC-active / PKC-inact-GAP | fig2_egfr Accession No. : 1 | fig2_egfr Pathway No. : 1 | 3.33333 | 4 | 4 | explicit E-S complex | Substrate GAP Product GAP* |
GAP acting as a Product in a reaction in fig2_egfr Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| dephosph-GAP | fig2_egfr Accession No. : 1 | Ras Pathway No. : 7 | 0.1 (s^-1) | 0 (s^-1) | - | - | Substrate GAP* Product GAP |