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Molecule Parameter List for L.EGFR | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| L.EGFR participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 2 | 0 | 0 | 1 | 1 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| fig2_egfr | 1 | Network | Shared_Object_fig2_egfr, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, EGFR, Sos, PLC_g, CaRegulation |
| This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here. | |||
L.EGFR acting as a Molecule in fig2_egfr Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| L.EGFR | fig2_egfr Accession No. : 1 | EGFR Pathway No. : 8 | 0 | 1000 | No | |
L.EGFR acting as an Enzyme in fig2_egfr Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | |
| 1 | L.EGFR / phosph_PLC_g | fig2_egfr Accession No. : 1 | EGFR Pathway No. : 8 | 0.333333 | 0.2 | 4 | explicit E-S complex | Substrate Ca.PLC_g Product Ca.PLC_g* |
| 2 | L.EGFR / phosph_Shc | fig2_egfr Accession No. : 1 | EGFR Pathway No. : 8 | 0.833333 | 0.2 | 4 | explicit E-S complex | Substrate SHC Product SHC* |
L.EGFR acting as a Substrate in a reaction in fig2_egfr Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| Internalize | fig2_egfr Accession No. : 1 | EGFR Pathway No. : 8 | 0.002 (s^-1) | 0.0003 (s^-1) | Keq = 0.165(uM) | 434.783sec | Substrate L.EGFR Product Internal_L.EGFR |
L.EGFR acting as a Product in a reaction in fig2_egfr Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| act_EGFR | fig2_egfr Accession No. : 1 | EGFR Pathway No. : 8 | 4.2 (uM^-1 s^-1) | 0.25 (s^-1) | Kd(bf) = 0.0595(uM) | - | Substrate EGF EGFR Product L.EGFR |