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Molecule Parameter List for DAG-Ca-PLA2*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

DAG-Ca-PLA2* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	1	0	0	0	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Synaptic_ Network	16	Network	Shared_Object_Synaptic_Network,  PKC,  PLA2,   PLCbeta,  Gq,  MAPK,   Ras,  EGFR,  Sos,   PLC_g,  CaMKII,  CaM,   PP1,  PP2B,  PKA,   AC,  CaRegulation
This model is an annotated version of the synaptic signaling network. The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated. Bhalla US Biophys J. 2002 Aug;83(2):740-52 Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62

DAG-Ca-PLA2* acting as a Molecule in  Synaptic_Network Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
DAG-Ca-PLA2*	Synaptic_ Network Accession No. : 16	PLA2 Pathway No. : 72	0	1000	No
Active form of PLA2 with DAG and Ca bound. DAG and Ca act in combination hence the need for this form in the model. Leslie and Channon (199) BBA 1045:261-270

DAG-Ca-PLA2* acting as an Enzyme in  Synaptic_Network Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
DAG-Ca-PLA2* / kenz	Synaptic_ Network Accession No. : 16	PLA2 Pathway No. : 72	20	60	4	explicit E-S complex	Substrate APC Product AA
Based on Leslie and Channon 1990 BBA 1045:261.

DAG-Ca-PLA2* acting as a Product in a reaction in  Synaptic_Network Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
DAG-Ca-PLA2-act	Synaptic_ Network Accession No. : 16	PLA2 Pathway No. : 72	0.003 (uM^-1 s^-1)	4 (s^-1)	Kd(bf) = 1333.3333(uM)	-	Substrate DAG PLA2-Ca* Product DAG-Ca-PLA2*
Synergistic activation of PLA2 by Ca and DAG. Based on Leslie and Channon 1990 BBA 1045:261 The Kd is rather large and may reflect the complications in measuring DAG. For this model it is not critical since DAG is held fixed.