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Molecule Parameter List for Blocked-rec-Gq | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color. | Statistics |
Blocked-rec-Gq participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Accession and Pathway Details | |
Accession Name | Accession No. | Accession Type | Pathway Link | Synaptic_ Network | 16 | Network | Shared_Object_Synaptic_Network, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, EGFR, Sos, PLC_g, CaMKII, CaM, PP1, PP2B, PKA, AC, CaRegulation | This model is an annotated version of the synaptic signaling network. The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated. Bhalla US Biophys J. 2002 Aug;83(2):740-52 Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62 |
Blocked-rec-Gq acting as a Molecule in Synaptic_Network Network
Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | Blocked-rec-Gq | Synaptic_ Network Accession No. : 16 | Gq Pathway No. : 74 | 0 | 1000 | No | This represents the blocked state of the receptor when bound to a competitive antagonist. Note that this is in the Gq bound form. Simulations had shown that with the available rates, the blocking was minimal if only the unbound receptor could bind the antagonist. |
Blocked-rec-Gq acting as a Product in a reaction in Synaptic_Network Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | Antag-bind-Rec-G q | Synaptic_ Network Accession No. : 16 | Gq Pathway No. : 74 | 60 (uM^-1 s^-1) | 0.01 (s^-1) | Kd(bf) = 0.0002(uM) | - | Substrate Rec-Gq mGluRAntag
Product Blocked-rec-Gq
| The rate consts give a total binding affinity of under 0.2 nM, good for a strong antagonist. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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