Enter a Search String

Special character and space not allowed in the query term. Search string should be at least 2 characters long.

Search in:

ALL Accession Pathway Molecule Enzyme Reaction Connected to

Search for

Match

Anything Exact Word Starting With

By

Name Notes Model

Molecule Parameter List for CaTransp-2Ca

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaTransp-2Ca participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	1	1

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Synaptic_ Network	16	Network	Shared_Object_Synaptic_Network,  PKC,  PLA2,   PLCbeta,  Gq,  MAPK,   Ras,  EGFR,  Sos,   PLC_g,  CaMKII,  CaM,   PP1,  PP2B,  PKA,   AC,  CaRegulation
This model is an annotated version of the synaptic signaling network. The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated. Bhalla US Biophys J. 2002 Aug;83(2):740-52 Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62

CaTransp-2Ca acting as a Molecule in  Synaptic_Network Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaTransp-2Ca	Synaptic_ Network Accession No. : 16	CaRegulation Pathway No. : 86	0	1000	No
This is equivalent to the enzyme-substrate complex. 2 Ca are bound to the transporter. The ATP is ignored.

CaTransp-2Ca acting as a Substrate in a reaction in  Synaptic_Network Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaTraspATPase	Synaptic_ Network Accession No. : 16	CaRegulation Pathway No. : 86	25 (s^-1)	0 (#^-2 s^-1)	Not applicable**	-	Substrate CaTransp-2Ca Product Ca-sequester Ca-sequester CaTransp
kCa3 = 2 * Ca transporter rate since each step has 2 Ca++. = 0.5 uM/sec from Lauffenburger and Linderman 1993 Receptors pg 200. The amount of the activated transporter is about 0.01 uM = 6e3 #. from runs. So 0.01uM * kf * 2 = 0.5 uM/sec (no back reaction) so kf = 25, kb = 0 Alternatively, 6e3 * kf = 0.25 * 6e5, giving the same kf

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

CaTransp-2Ca acting as a Product in a reaction in  Synaptic_Network Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Ca-bind-to-Trans p	Synaptic_ Network Accession No. : 16	CaRegulation Pathway No. : 86	3600 (uM^-2 s^-1)	144 (s^-1)	Kd(bf) = 0.04(uM)	-	Substrate CaTransp Ca_intracell Ca_intracell Product CaTransp-2Ca
Rates from Lauffenberger and Linderman 1993 Receptors pg 200. Kd = KCa2 = 0.2 uM.