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Molecule Parameter List for IP3_3K_CaM | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 24 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP3_3K_CaM acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP3_3K_CaM | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP3-3K
Pathway No. : 124 | 0 | 1000 | No | | 2-2.5 fold increase in enzyme activity due to CaM binding CaM binding involves Trp165 Erneux et al; Biochem 214, 497-501 (1993) |
IP3_3K_CaM acting as an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | IP3_3K_CaM /
ip3-3k-CaM
| Osc_Ca_
IP3metabolism
Accession No. : 24 | IP3-3K
Pathway No. : 124 | 2.8001 | 10.5 | 4.0001 | explicit E-S complex | Substrate
IP3(145)
Product
IP4(1345)
| | from Erneux et al, Biochem 214; 1993 2-2.5 fold more active than ip3-3k but Km is doubled, hence Vmax adjusted accordingly. |
IP3_3K_CaM acting as a Substrate for an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | tot_CaM_CaMKII /
CaM-CaMK-phos1 | Osc_Ca_
IP3metabolism
Accession No. : 24 | CaMKII
Pathway No. : 121 | 1.59998 | 0.5 | 4 | explicit E-S complex | Substrate
IP3_3K_CaM
Product
IP3_3K_CaM*
| | | rates referred from standard CaM-CaMKII phosphorylation rates | | 2 | tot_autonomous_
CaMKII /
CaMK-phos1 | Osc_Ca_
IP3metabolism
Accession No. : 24 | CaMKII
Pathway No. : 121 | 2.49995 | 0.5 | 4 | explicit E-S complex | Substrate
IP3_3K_CaM
Product
IP3_3K_CaM*
| | | rates referred from standard CaMKII phosphorylation rates |
IP3_3K_CaM acting as a Product in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 3K-bind-CaM | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP3-3K
Pathway No. : 124 | 19.2312
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.052(uM) | - | Substrate
CaM-Ca4
IP3_3K
Product
IP3_3K_CaM
| | Communi et al, EMBO J 16; 1997 non-phosphorylated 3kinase with low sensitivity to CaM binding (Kd = 52nM) |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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