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Molecule Parameter List for IP_1pase

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

IP_1pase participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	2	0	0	1	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Osc_Ca_ IP3metabolism	24	Network	MIPP,  CaMKII,  CaM,   PKC,  IP3-3K,  Gq,   PLCbeta,  134_dephos,  145_dephos,   IP4-system,  IHP-system,  1345_dephos,   CaRegulation,  Othmer-Tang-model
This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316.

IP_1pase acting as a Molecule in  Osc_Ca_IP3metabolism Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
IP_1pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	5.0163	1000	No
from Inhorn and Majerus; JBC 262(33), 1987 pp 15946-15952 InsP-1-phosphatase has two enzyme activities against Ins(14)P2 and Ins(134)P3 respectively

IP_1pase acting as an Enzyme in  Osc_Ca_IP3metabolism Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	IP_1pase / ip2_1pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	5.00005	2	4	explicit E-S complex	Substrate IP2(14) Product IP1(4)
	from Inhorn and Majerus, JBC 1987 Vmax reduced from 5.625 to 2 to maintain levels of IP2(14)
2	IP_1pase / ip3_1pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	20.0021	4.125	4	explicit E-S complex	Substrate IP3(134) Product IP2(34)
	Ins(134) 1-phosphatase activity of InsP 1-phosphatase from Inhorn and Majerus, JBC 262; 1987

IP_1pase acting as a Substrate in a reaction in  Osc_Ca_IP3metabolism Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
Ca-inhib-1pase	Osc_Ca_ IP3metabolism Accession No. : 24	145_dephos Pathway No. : 128	1 (uM^-1 s^-1)	6 (s^-1)	Kd(bf) = 5.9999(uM)	-	Substrate Ca IP_1pase Product Ca-1pase-cmplx
Ki from Inhorn & Majerus, BiochemJ 262(33); 1987: 15946-52