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Molecule Parameter List for Ca

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

Ca participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	12	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII	33	Network	Shared_Object_CaMKII, CaM, CaMKII, CaN
This is a deterministic, point kinetics approximation to the dendritic spine CaMKII model described in William R. Holmes J Comput Neurosci. (2000) 8(1):65-85. Rates are the same but the responses differ somewhat because this model does not include the stochastic and diffusive calculations of the original.

Ca acting as a Molecule in CaMKII Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
Ca	CaMKII Accession No. : 33	Shared_Object_ CaMKII Pathway No. : 172	0.07	0.1309	No
70 nM initial conc from Holmes.

Ca acting as a Substrate in a reaction in CaMKII Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	CaMKII-CaMCa-bin d-Ca	CaMKII Accession No. : 33	CaMKII Pathway No. : 174	100.004 (uM^-1 s^-1)	20 (s^-1)	Kd(bf) = 0.2(uM)	-	Substrate CAMKII-CaMCa Ca Product CaMKII-CaMCa2
2	CaMKII-CaMCa2-bi nd-Ca	CaMKII Accession No. : 33	CaMKII Pathway No. : 174	100.004 (uM^-1 s^-1)	2 (s^-1)	Kd(bf) = 0.02(uM)	-	Substrate Ca CaMKII-CaMCa2 Product CaMKII-CaMCa3
3	CaMKII-CaMCa3-bi nd-Ca	CaMKII Accession No. : 33	CaMKII Pathway No. : 174	100.004 (uM^-1 s^-1)	100 (s^-1)	Kd(bf) = 1(uM)	-	Substrate Ca CaMKII-CaMCa3 Product CaMKII-CaMCa4
4	CaM-bind-Ca	CaMKII Accession No. : 33	CaM Pathway No. : 173	1 (uM^-1 s^-1)	20 (s^-1)	Kd(bf) = 19.9992(uM)	-	Substrate Ca CaM Product CaMCa
5	CaMCa-bind-Ca	CaMKII Accession No. : 33	CaM Pathway No. : 173	33.2998 (uM^-1 s^-1)	20 (s^-1)	Kd(bf) = 0.6006(uM)	-	Substrate Ca CaMCa Product CaMCa2
6	CaMCa2-bind-Ca	CaMKII Accession No. : 33	CaM Pathway No. : 173	5 (uM^-1 s^-1)	500 (s^-1)	Kd(bf) = 99.9994(uM)	-	Substrate Ca CaMCa2 Product CaMCa3
7	CaMCa3-bind-Ca	CaMKII Accession No. : 33	CaM Pathway No. : 173	100.004 (uM^-1 s^-1)	500 (s^-1)	Kd(bf) = 4.9998(uM)	-	Substrate Ca CaMCa3 Product CaMCa4
8	CaMKII-CaM-bind- Ca	CaMKII Accession No. : 33	CaMKII Pathway No. : 174	4 (uM^-1 s^-1)	20 (s^-1)	Kd(bf) = 5(uM)	-	Substrate Ca CaMKII-CaM Product CAMKII-CaMCa
9	CaN-CaM-bind-Ca	CaMKII Accession No. : 33	CaN Pathway No. : 175	100.004 (uM^-1 s^-1)	60 (s^-1)	Kd(bf) = 0.6(uM)	-	Substrate Ca CaN-CaM Product CaN-CaMCa
10	CaN-CaMCa-bind-C a	CaMKII Accession No. : 33	CaN Pathway No. : 175	100.004 (uM^-1 s^-1)	10 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate Ca CaN-CaMCa Product CaN-CaMCa2
11	CaN-CaMCa2-bind- Ca	CaMKII Accession No. : 33	CaN Pathway No. : 175	100.004 (uM^-1 s^-1)	8 (s^-1)	Kd(bf) = 0.08(uM)	-	Substrate Ca CaN-CaMCa2 Product CaN-CaMCa3
12	CaN-CaMCa3-bind- Ca	CaMKII Accession No. : 33	CaN Pathway No. : 175	100.004 (uM^-1 s^-1)	30 (s^-1)	Kd(bf) = 0.3(uM)	-	Substrate Ca CaN-CaMCa3 Product CaN-CaMCa4

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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