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Molecule Parameter List for MKP-1-ser359* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | mkp1_feedback_
effects | 4 | Network |
Shared_Object_mkp1_feedback_effects, Sos, PKC,
MAPK, PLA2, Ras,
PDGFR | | This is a network involving the MAPK-PKC feedback loop with input from the PDGFR in the synapse. The distinctive feature of this model is that it includes MKP-1 induction by MAPK, and the consequent inhibitory regulation of MAPK and the feedback loop. Lots of interesting dynamics arise from this. This link provides supplementary material for the paper Bhalla US et al. Science (2002) 297(5583):1018-23. In the form of several example simulations and demos for the figures in the paper. |
MKP-1-ser359* acting as a Molecule in mkp1_feedback_effects Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | MKP-1-ser359* | mkp1_feedback_
effects
Accession No. : 4 | MAPK
Pathway No. : 35 | 0 | 1000 | No | | Singly phosphorylated form of MKP-1. Slower ubiquitination. See Brondello et al 1999 Science 286:2514 From the simulations, this form has a rather low and transient level. So I do not include it in the dephosphorylation of MAPK. |
MKP-1-ser359* acting as a Summed Molecule in mkp1_feedback_effects Network
MKP-1-ser359* acting as a Substrate for an Enzyme in mkp1_feedback_effects Network
MKP-1-ser359* acting as a Product of an Enzyme in mkp1_feedback_effects Network
MKP-1-ser359* acting as a Substrate in a reaction in mkp1_feedback_effects Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | turnover_MKP1* | mkp1_feedback_
effects
Accession No. : 4 | MAPK
Pathway No. : 35 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
MKP-1-ser359*
Product
Ubiquitination
| | | Rate of turnover of phosph form of MKP1 is from Brondello et al Science 286:2514 1999. Tau is about 150 min though it is not a clean exponential falloff. | | 2 | MKP-1*dephosph | mkp1_feedback_
effects
Accession No. : 4 | MAPK
Pathway No. : 35 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
MKP-1-ser359*
Product
MKP-1
| | | 24 Apr 2K: Based on 12 Feb 2K: Scaled up 10x so kf=0.01, kb=0 13 Apr 2001: MKP1* Goes down too fast, equil amount too small. Note that tau for turnover is 150 min. Doesn't make sense to have this tau be so much less. Go for 1e-4 |
MKP-1-ser359* acting as a Product in a reaction in mkp1_feedback_effects Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | MKP-1**dephosph | mkp1_feedback_
effects
Accession No. : 4 | MAPK
Pathway No. : 35 | 0.0001
(s^-1) | 0
(s^-1) | - | - | Substrate
MKP-1**
Product
MKP-1-ser359*
| | 24 Apr 2K, based on 12 Feb 2K: Scaled up 10x to kf=0.01, kb=0 13 Apr 2001. Slowing down to 0.0001 to match turnover rates. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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