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Molecule Parameter List for tot_CaM_CaMKII

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

tot_CaM_CaMKII participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	2	2	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII_model3	63	Network	Shared_Object_CaMKII_model3,  CaMKII,  CaM,   PP1,  PP2B,  PP1_PSD,   AC,  PKA
This is the complete model of CaMKII bistability, model 3. It exhibits bistability in CaMKII activation due to autophosphorylation at the PSD and local saturation of PP1. This version of model 3 includes PKA regulatory input. This has little effect on the deterministic calculations, but the PKA pathway introduces a lot of noise which causes a difference in stochastic runs.

tot_CaM_CaMKII acting as a Molecule in  CaMKII_model3 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
tot_CaM_CaMKII	CaMKII_model3 Accession No. : 63	CaMKII Pathway No. : 264	0	0.09	No

tot_CaM_CaMKII acting as a Summed Molecule in  CaMKII_model3 Network

	Accession Nane	Pathway Name	Target	Input
1	CaMKII_model3 Accession No. : 63	CaMKII Pathway No. : 264	tot_CaM_CaMKII	CaMKII-CaM CaMKII-thr286*-C aM
2	CaMKII_model3 Accession No. : 63	Shared_Object_ CaMKII_model3 Pathway No. : 263	act_CaMKII_cyt	tot_CaM_CaMKII tot_autonomous_ CaMKII

tot_CaM_CaMKII acting as an Enzyme in  CaMKII_model3 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot_CaM_CaMKII / CaM_act_305	CaMKII_model3 Accession No. : 63	CaMKII Pathway No. : 264	226.998	6	4	explicit E-S complex	Substrate CaMKII-thr286 Product CaMKII***
	Rates from autocamtide phosphorylation, from Hanson and Schulman JBC 267:24 17216-17224 1992. Jan 1 1998: Speed up 12x to match fig 5.
2	tot_CaM_CaMKII / CaM_act_286	CaMKII_model3 Accession No. : 63	CaMKII Pathway No. : 264	226.998	0.5	4	explicit E-S complex	Substrate CaMKII-CaM Product CaMKII-thr286*-C aM