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Molecule Parameter List for PP1-active_CaMKII_PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

PP1-active_CaMKII_PSD participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	5	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_CaMKII_ weak_coupling	65	Network	Shared_Object_AMPAR_CaMKII_weak_coupling,  CaMKII,  CaM,   PP1,  PP2B,  PP1_PSD,   AMPAR,  PKA,  AC,   AMPAR_memb,  PP1_CaMKII_PSD,  CaMKII_PSD
This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.

PP1-active_CaMKII_PSD acting as a Molecule in  AMPAR_CaMKII_weak_coupling Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PP1-active_CaMKII_PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	PP1_CaMKII_PSD Pathway No. : 291	2	0.01	No
Cohen et al Meth Enz 159 390-408 is main source of info conc = 1.8 uM in their study, here it is almost the same. In this model of weak coupling between CaMKII and AMPAR, this phosphatase pool acts only on the CaMKII present in the PSD.

PP1-active_CaMKII_PSD acting as an Enzyme in  AMPAR_CaMKII_weak_coupling Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PP1-active_ CaMKII_PSD / Deph-thr286	AMPAR_CaMKII_ weak_coupling Accession No. : 65	PP1_CaMKII_PSD Pathway No. : 291	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr286-Ca M-PSD Product CaMKII-CaM-PSD
2	PP1-active_ CaMKII_PSD / Deph-thr286b	AMPAR_CaMKII_ weak_coupling Accession No. : 65	PP1_CaMKII_PSD Pathway No. : 291	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr286-PS D Product CaMKII-PSD
3	PP1-active_ CaMKII_PSD / Deph-thr305	AMPAR_CaMKII_ weak_coupling Accession No. : 65	PP1_CaMKII_PSD Pathway No. : 291	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII***-PSD Product CaMKII-thr286-PS D
4	PP1-active_ CaMKII_PSD / Deph-thr286c	AMPAR_CaMKII_ weak_coupling Accession No. : 65	PP1_CaMKII_PSD Pathway No. : 291	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII***-PSD Product CaMKII-thr305-PS D
5	PP1-active_ CaMKII_PSD / Deph-thr305a	AMPAR_CaMKII_ weak_coupling Accession No. : 65	PP1_CaMKII_PSD Pathway No. : 291	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr305-PS D Product CaMKII-PSD