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Molecule Parameter List for CaMKII-thr305-PSD | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CaMKII-thr305-PSD participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
weak_coupling | 65 | Network | Shared_Object_AMPAR_CaMKII_weak_coupling, CaMKII, CaM, PP1, PP2B, PP1_PSD, AMPAR, PKA, AC, AMPAR_memb, PP1_CaMKII_PSD, CaMKII_PSD |
| This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on. | |||
CaMKII-thr305-PSD acting as a Molecule in AMPAR_CaMKII_weak_coupling Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| CaMKII-thr305-PSD | weak_coupling Accession No. : 65 | CaMKII_PSD Pathway No. : 292 | 0 | 0.01 | No | |
CaMKII-thr305-PSD acting as a Summed Molecule in AMPAR_CaMKII_weak_coupling Network
| Accession Name | Pathway Name | Target | Input |
weak_coupling Accession No. : 65 | CaMKII_PSD Pathway No. : 292 | tot_CaMKII_PSD | actCaMKII-PSD CaMKII-PSD D |
CaMKII-thr305-PSD acting as a Substrate for an Enzyme in AMPAR_CaMKII_weak_coupling Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
CaMKII_PSD / Deph-thr305a | weak_coupling Accession No. : 65 | PP1_CaMKII_PSD Pathway No. : 291 | 2.00001 | 0.2 | 4 | explicit E-S complex | Substrate D Product CaMKII-PSD |
CaMKII-thr305-PSD acting as a Product of an Enzyme in AMPAR_CaMKII_weak_coupling Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents |
CaMKII_PSD / Deph-thr286c | weak_coupling Accession No. : 65 | PP1_CaMKII_PSD Pathway No. : 291 | 2.00001 | 0.2 | 4 | explicit E-S complex | Substrate CaMKII***-PSD Product D |
CaMKII-thr305-PSD acting as a Substrate in a reaction in AMPAR_CaMKII_weak_coupling Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents |
| back_2 | weak_coupling Accession No. : 65 | CaMKII_PSD Pathway No. : 292 | 0.3 (s^-1) | 0 (#^-1 s^-1) | Not applicable** | - | Substrate D Product CaMK-thr305 NMDAR |
| Same as for back_1 | |||||||