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Molecule Parameter List for PKC-cytosolic

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*PKC-cytosolic* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	25	0	0	0	0	74	24

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_bhalla_ 2007_ReacDiff1_ 1e-12	81	Network	Shared_Object_Ajay_bhalla_2007_ReacDiff1_1e-12, PKC, MAPK, Ras, CaM, PKM, chain, kinetics, PKC, MAPK, Ras, CaM, PKM, kinetics[1], PKC, MAPK, Ras, CaM, PKM, kinetics[2], PKC, MAPK, Ras, CaM, PKM, kinetics[3], PKC, MAPK, MAPK, Ras, CaM, PKM, kinetics[4], PKC, MAPK, Ras, CaM, PKM, kinetics[5], PKC, MAPK, Ras, kinetics[6], CaM, PKM, PKC, MAPK, Ras, CaM, PKM, kinetics[7], PKC, Ras, CaM, PKM, kinetics[8], PKC, MAPK, Ras, CaM, PKM, kinetics[9], PKC, MAPK, Ras, CaM, PKM, kinetics[10], PKC, MAPK, Ras, CaM, PKM, kinetics[11], PKC, MAPK, Ras, CaM, PKM, kinetics[12], PKC, MAPK, Ras, CaM, PKM, kinetics[13], PKC, MAPK, Ras, CaM, PKM, kinetics[14], PKC, MAPK, Ras, CaM, PKM, kinetics[15], PKC, MAPK, Ras, CaM, PKM, kinetics[16], PKC, MAPK, Ras, CaM, PKM, kinetics[17], PKC, MAPK, Ras, CaM, PKM, kinetics[18], PKC, MAPK, Ras, CaM, PKM, kinetics[19], PKC, MAPK, Ras, CaM, PKM, kinetics[20], PKC, MAPK, Ras, CaM, PKM, kinetics[21], PKC, MAPK, Ras, CaM, PKM, kinetics[22], PKC, MAPK, Ras, CaM, PKM, kinetics[23], PKC, MAPK, Ras, CaM, PKM
This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_PKM model. The original single-compartment model is repeated 25 times. In addition, a subset (27 out of 42) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. For D = 1e-12 m^2/sec (i.e., 1 micron^2/sec ) the kf and kb of this reaction for these 10 micron compartments are both 0.01/sec. For D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) the kf and kb are 0.001/sec. The stimulus file pkm_mapk22_diff_1e-12_Fig4A which was used for the model to replicate Figure 4A from the paper. This stimulus file pkm_mapk22_diff_1e-12_Fig4G which was used for the model to replicate Figure 4G from the paper

PKC-cytosolic acting as a Molecule in Ajay_bhalla_2007_ReacDiff1_1e-12 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 376	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 383	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 389	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 395	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 401	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 408	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 414	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 420	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 426	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 431	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 437	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 443	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 449	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 455	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 461	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 467	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 473	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 479	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 485	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 491	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 497	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 503	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 509	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 515	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen
PKC-cytosolic	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 521	1	1.5	No
Marquez et al J. Immun 149,2560(92) est 1e6/cell for chromaffin cells We will use 1 uM as our initial concen

PKC-cytosolic acting as a Substrate in a reaction in Ajay_bhalla_2007_ReacDiff1_1e-12 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 376	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
2	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 376	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
3	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
4	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 383	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
5	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 383	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
6	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
7	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 401	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
8	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 389	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
9	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 389	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
10	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
11	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 395	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
12	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 395	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
13	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
14	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 426	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
15	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 401	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
16	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
17	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 408	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
18	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 408	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
19	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
20	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 414	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
21	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 414	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
22	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
23	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 420	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
24	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 420	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
25	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
26	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 473	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
27	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 473	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
28	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 426	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
29	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
30	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 431	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
31	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 431	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
32	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
33	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 437	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
34	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 437	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
35	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
36	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 443	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
37	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 443	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
38	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
39	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 449	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
40	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 449	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
41	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
42	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 455	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
43	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 455	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
44	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
45	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 461	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
46	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 461	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
47	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
48	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 467	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
49	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 467	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
50	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
51	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
52	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 479	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
53	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 479	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
54	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
55	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 485	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
56	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 485	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
57	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
58	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 491	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
59	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 491	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
60	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
61	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 497	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
62	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 497	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
63	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
64	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 503	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
65	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 503	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
66	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
67	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 509	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
68	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 509	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
69	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
70	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 515	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
71	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 515	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9
72	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
73	PKC-act-by-Ca	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 521	0.6 (uM^-1 s^-1)	0.5 (s^-1)	Kd(bf) = 0.8333(uM)	-	Substrate Ca PKC-cytosolic Product PKC-Ca
	Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
74	PKC-n-DAG	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	PKC Pathway No. : 521	0.0006 (uM^-1 s^-1)	0.1 (s^-1)	Kd(bf) = 166.6664(uM)	-	Substrate DAG PKC-cytosolic Product PKC-DAG
	kf raised 10 X based on Shinomura et al PNAS 88 5149-5153 1991 closer analysis of Shinomura et al: kf now 1e-8 (was 1.66e-8). Further tweak. To get sufficient AA synergy, increase kf to 1.5e-8 26 June 1996: Corrected DAG levels: reduce kf by 15x from 1.5e-8 to 1e-9

PKC-cytosolic acting as a Product in a reaction in Ajay_bhalla_2007_ReacDiff1_1e-12 Network

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
2	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
3	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
4	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
5	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
6	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
7	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
8	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
9	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
10	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
11	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
12	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
13	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
14	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
15	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
16	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
17	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
18	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
19	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
20	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
21	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
22	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
23	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic
24	diff	Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Accession No. : 81	Shared_Object_ Ajay_bhalla_ 2007_ReacDiff1_ 1e-12 Pathway No. : 375	0.01 (s^-1)	0.01 (s^-1)	Keq = 1(uM)	50sec	Substrate PKC-cytosolic Product PKC-cytosolic

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