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Molecule Parameter List for PLA2*-Ca

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PLA2*-Ca participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences25025002449

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_ReacDiff3
    		• 84NetworkShared_Object_Ajay_Bhalla_2007_ReacDiff3,  PKC,  PLA2,  
    MAPK,  PLA2,  Ras,  CaM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  kinetics[1],  
    PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[2],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[3],  
    PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[4],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[5],  
    PKC,  PLA2,  MAPK,  Ras,  MAPK,  CaM,  kinetics[6],  PKC,  PLA2,  MAPK,  Ras,  
    CaM,  kinetics[7],  PKC,  PLA2,  MAPK,  Ras,  CaM,  PKC,  kinetics[8],  PLA2,  
    MAPK,  Ras,  CaM,  kinetics[9],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[10],  
    PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[11],  PKC,  PLA2,  MAPK,  Ras,  CaM,  
    kinetics[12],  PKC,  PLA2,  Ras,  CaM,  kinetics[13],  PKC,  PLA2,  MAPK,  
    Ras,  CaM,  kinetics[14],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[15],  
    PKC,  PLA2,  MAPK,  Ras,  kinetics[16],  CaM,  PKC,  PLA2,  MAPK,  Ras,  CaM,  
    kinetics[17],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[18],  PKC,  PLA2,  
    MAPK,  Ras,  CaM,  kinetics[19],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[20],  
    PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[21],  PKC,  PLA2,  MAPK,  Ras,  CaM,  
    kinetics[22],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[23],  PKC,  PLA2,  
    MAPK,  Ras,  CaM 
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
    In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
    The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
    The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.

    PLA2*-Ca acting as a Molecule in      Ajay_Bhalla_2007_ReacDiff3 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 920    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 922    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 933    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 939    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 945    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 951    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 957    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 964    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 970    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 976    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 982    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 988    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 994    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1000    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1005    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1011    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1017    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1023    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1029    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1035    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1041    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1047    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1053    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1059    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.
    PLA2*-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1065    		0125.7No
    Phosphorylated form of PLA2. Still need to hook it up using kinases. PKA: Wightman et al JBC 257 pp6650 1982 PKC: Many refs, eg Gronich et al JBC 263 pp 16645, 1988 but see Lin etal MAPK: Lin et al, Cell 72 pp 269, 1993. Show 3x with MAPK but not PKC alone Do not know if there is a Ca requirement for active phosphorylated state.

    PLA2*-Ca acting as an Enzyme in      Ajay_Bhalla_2007_ReacDiff3 Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 920    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    2PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 922    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    3PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 933    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    4PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 939    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    5PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 945    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    6PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 951    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    7PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 957    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    8PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 964    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    9PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 970    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    10PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 976    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    11PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 982    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    12PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 988    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    13PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 994    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    14PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1000    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    15PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1005    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    16PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1011    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    17PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1017    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    18PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1023    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    19PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1029    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    20PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1035    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    21PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1041    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    22PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1047    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    23PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1053    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    24PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1059    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3
    25PLA2*-Ca /
    kenz
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1065    		201204explicit E-S complexSubstrate
    APC

    Product
    AA
        This form should be 3 to 6 times as fast as the Ca-only form. I have scaled by 4x which seems to give a 5x rise. 10x raise Oct 22 12 x oct 24, changed k2 = 4 * k3

    PLA2*-Ca acting as a Substrate in a reaction in      Ajay_Bhalla_2007_ReacDiff3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    3diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    7diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    15diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca

    PLA2*-Ca acting as a Product in a reaction in      Ajay_Bhalla_2007_ReacDiff3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    2PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 920    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    3diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    4PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 922    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    6PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 933    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    7diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    8PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 939    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    10PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 945    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    12PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 951    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    14PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 957    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    15diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    16PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1000    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    18PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 964    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    20PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 970    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    22PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 976    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    24PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 982    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    25diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    26PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 988    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    27diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    28PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 994    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    29diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    30PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1005    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    31diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    32PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1011    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    33diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    34PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1017    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    35diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    36PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1023    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    37diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    38PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1029    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    39diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    40PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1035    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    41diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    42PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1041    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    43diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    44PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1047    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    45diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    46PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1053    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    47diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    PLA2*-Ca

    Product
    PLA2*-Ca
    48PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1059    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....
    49PLA2*-Ca-act
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• PLA2
    Pathway No. : 1065    		6
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0167(uM)-Substrate
    Ca
    PLA2*

    Product
    PLA2*-Ca
      To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien....


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