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Molecule Parameter List for PLA2* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_
2007_ReacDiff3 | 84 | Network | Shared_Object_Ajay_Bhalla_2007_ReacDiff3, PKC, PLA2,
MAPK, PLA2, Ras, CaM, chain, kinetics, PKC, MAPK, Ras, CaM, kinetics[1],
PKC, PLA2, MAPK, Ras, CaM, kinetics[2], PKC, PLA2, MAPK, Ras, CaM, kinetics[3],
PKC, PLA2, MAPK, Ras, CaM, kinetics[4], PKC, PLA2, MAPK, Ras, CaM, kinetics[5],
PKC, PLA2, MAPK, Ras, MAPK, CaM, kinetics[6], PKC, PLA2, MAPK, Ras,
CaM, kinetics[7], PKC, PLA2, MAPK, Ras, CaM, PKC, kinetics[8], PLA2,
MAPK, Ras, CaM, kinetics[9], PKC, PLA2, MAPK, Ras, CaM, kinetics[10],
PKC, PLA2, MAPK, Ras, CaM, kinetics[11], PKC, PLA2, MAPK, Ras, CaM,
kinetics[12], PKC, PLA2, Ras, CaM, kinetics[13], PKC, PLA2, MAPK,
Ras, CaM, kinetics[14], PKC, PLA2, MAPK, Ras, CaM, kinetics[15],
PKC, PLA2, MAPK, Ras, kinetics[16], CaM, PKC, PLA2, MAPK, Ras, CaM,
kinetics[17], PKC, PLA2, MAPK, Ras, CaM, kinetics[18], PKC, PLA2,
MAPK, Ras, CaM, kinetics[19], PKC, PLA2, MAPK, Ras, CaM, kinetics[20],
PKC, PLA2, MAPK, Ras, CaM, kinetics[21], PKC, PLA2, MAPK, Ras, CaM,
kinetics[22], PKC, PLA2, MAPK, Ras, CaM, kinetics[23], PKC, PLA2,
MAPK, Ras, CaM | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. |
PLA2* acting as a Molecule in Ajay_Bhalla_2007_ReacDiff3 Network
PLA2* acting as a Product of an Enzyme in Ajay_Bhalla_2007_ReacDiff3 Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 2 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics
Pathway No. : 926 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 3 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[1]
Pathway No. : 931 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 4 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[2]
Pathway No. : 937 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 5 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[3]
Pathway No. : 943 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 6 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[4]
Pathway No. : 949 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 7 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[5]
Pathway No. : 955 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 8 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[6]
Pathway No. : 962 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 9 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[7]
Pathway No. : 968 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 10 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[8]
Pathway No. : 975 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 11 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[9]
Pathway No. : 980 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 12 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[10]
Pathway No. : 986 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 13 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[11]
Pathway No. : 992 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 14 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[12]
Pathway No. : 998 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 15 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[13]
Pathway No. : 1003 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 16 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[14]
Pathway No. : 1009 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 17 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[15]
Pathway No. : 1015 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 18 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[16]
Pathway No. : 1020 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 19 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[17]
Pathway No. : 1027 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 20 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[18]
Pathway No. : 1033 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 21 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[19]
Pathway No. : 1039 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 22 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[20]
Pathway No. : 1045 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 23 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[21]
Pathway No. : 1051 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 24 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[22]
Pathway No. : 1057 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 | | 25 | MAPK* /
MAPK* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | kinetics[23]
Pathway No. : 1063 | 25.6405 | 10 | 4 | explicit E-S complex | Substrate
PLA2-cytosolic
Product
PLA2*
| | | Km = 25uM @ 50 uM ATP and 1mg/ml MBP (huge XS of substrate) Vmax = 4124 pmol/min/ml at a conc of 125 pmol/ml of enz, so: k3 = .5/sec (rate limiting) k1 = (k2 + k3)/Km = (.5 + 0)/(25*6e5) = 2e-8 (#/cell)^-1 #s from Sanghera et al JBC 265 pp 52 , 1990. From Nemenoff et al JBC 268(3):1960-1964 - using Sanghera's 1e-4 ratio of MAPK to protein, we get k3 = 7/sec from 1000 pmol/min/mg fig 5 |
PLA2* acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff3 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 2 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 920 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 3 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 920 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 4 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 5 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 922 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 6 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 922 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 7 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 8 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 933 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 9 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 933 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 10 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 11 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 939 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 12 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 939 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 13 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 14 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 945 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 15 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 945 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 16 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 17 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 951 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 18 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 951 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 19 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 20 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 957 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 21 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 957 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 22 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 23 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1000 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 24 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1000 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 25 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 26 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 964 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 27 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 964 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 28 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 29 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 970 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 30 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 970 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 31 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 32 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 976 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 33 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 976 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 34 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 35 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 982 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 36 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 982 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 37 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 38 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 988 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 39 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 988 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 40 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 41 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 994 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 42 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 994 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 43 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 44 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1005 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 45 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1005 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 46 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 47 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1011 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 48 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1011 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 49 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 50 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1017 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 51 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1017 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 52 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 53 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1023 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 54 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1023 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 55 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 56 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1029 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 57 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1029 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 58 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 59 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1035 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 60 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1035 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 61 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 62 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1041 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 63 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1041 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 64 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 65 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1047 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 66 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1047 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 67 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 68 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1053 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 69 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1053 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 70 | diff | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | Shared_Object_
Ajay_Bhalla_
2007_ReacDiff3
Pathway No. : 918 | 0.001
(s^-1) | 0.001
(s^-1) | Keq = 1(uM) | 500sec | Substrate
PLA2*
Product
PLA2*
| | 71 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1059 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 72 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1059 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
| | 73 | PLA2*-Ca-act | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1065 | 6
(uM^-1 s^-1) | 0.1
(s^-1) | Kd(bf) = 0.0167(uM) | - | Substrate
Ca
PLA2*
Product
PLA2*-Ca
| | | To start off, same kinetics as the PLA2-Ca-act direct pathway. Oops ! Missed out the Ca input to this pathway first time round. Let's raise the forward rate about 3x to 5e-6. This will let us reduce the rather high rates we have used for the kenz on PLA2*-Ca. In fact, it may be that the rates are not that different, just that this pathway for getting the PLA2 to the memb is more efficien.... | | 74 | dephosphorylate-
PLA2* | Ajay_Bhalla_
2007_ReacDiff3
Accession No. : 84 | PLA2
Pathway No. : 1065 | 0.17
(s^-1) | 0
(s^-1) | - | - | Substrate
PLA2*
Product
PLA2-cytosolic
|
PLA2* acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff3 Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
|
