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Molecule Parameter List for CaM-GEF

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaM-GEF* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	25	0	25	0	0	24	49

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
Ajay_Bhalla_ 2007_ReacDiff3	84	Network	Shared_Object_Ajay_Bhalla_2007_ReacDiff3, PKC, PLA2, MAPK, PLA2, Ras, CaM, chain, kinetics, PKC, MAPK, Ras, CaM, kinetics[1], PKC, PLA2, MAPK, Ras, CaM, kinetics[2], PKC, PLA2, MAPK, Ras, CaM, kinetics[3], PKC, PLA2, MAPK, Ras, CaM, kinetics[4], PKC, PLA2, MAPK, Ras, CaM, kinetics[5], PKC, PLA2, MAPK, Ras, MAPK, CaM, kinetics[6], PKC, PLA2, MAPK, Ras, CaM, kinetics[7], PKC, PLA2, MAPK, Ras, CaM, PKC, kinetics[8], PLA2, MAPK, Ras, CaM, kinetics[9], PKC, PLA2, MAPK, Ras, CaM, kinetics[10], PKC, PLA2, MAPK, Ras, CaM, kinetics[11], PKC, PLA2, MAPK, Ras, CaM, kinetics[12], PKC, PLA2, Ras, CaM, kinetics[13], PKC, PLA2, MAPK, Ras, CaM, kinetics[14], PKC, PLA2, MAPK, Ras, CaM, kinetics[15], PKC, PLA2, MAPK, Ras, kinetics[16], CaM, PKC, PLA2, MAPK, Ras, CaM, kinetics[17], PKC, PLA2, MAPK, Ras, CaM, kinetics[18], PKC, PLA2, MAPK, Ras, CaM, kinetics[19], PKC, PLA2, MAPK, Ras, CaM, kinetics[20], PKC, PLA2, MAPK, Ras, CaM, kinetics[21], PKC, PLA2, MAPK, Ras, CaM, kinetics[22], PKC, PLA2, MAPK, Ras, CaM, kinetics[23], PKC, PLA2, MAPK, Ras, CaM
This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times. In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec. The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation. The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.

CaM-GEF acting as a Molecule in Ajay_Bhalla_2007_ReacDiff3 Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 923	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 929	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 935	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 959	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 941	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 947	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 953	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 966	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 972	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 978	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 984	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 990	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 996	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1001	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1007	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1013	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1019	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1025	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1031	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1037	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1043	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1049	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1055	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1061	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995
CaM-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1067	0	125.7	No
See Farnsworth et al Nature 376 524-527 1995

CaM-GEF acting as an Enzyme in Ajay_Bhalla_2007_ReacDiff3 Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 923	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
2	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 929	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
3	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 935	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
4	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 959	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
5	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 941	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
6	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 947	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
7	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 953	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
8	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 966	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
9	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 972	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
10	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 978	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
11	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 984	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
12	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 990	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
13	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 996	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
14	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1001	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
15	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1007	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
16	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1013	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
17	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1019	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
18	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1025	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
19	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1031	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
20	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1037	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
21	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1043	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
22	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1049	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
23	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1055	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
24	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1061	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras
25	CaM-GEF / CaM-GEF-act-ras	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1067	0.505038	0.1	4	explicit E-S complex	Substrate GDP-Ras Product GTP-Ras
	Kinetics same as GEF-bg_act-ras

CaM-GEF acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff3 Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
2	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
3	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
4	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
5	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
6	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
7	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
8	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
9	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
10	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
11	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
12	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
13	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
14	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
15	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
16	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
17	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
18	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
19	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
20	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
21	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
22	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
23	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
24	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF

CaM-GEF acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff3 Network

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 923	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
2	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
3	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 929	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
4	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
5	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 935	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
6	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
7	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 959	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
8	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 941	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
9	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
10	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 947	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
11	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
12	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 953	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
13	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
14	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
15	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 966	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
16	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
17	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 972	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
18	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
19	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 978	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
20	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
21	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 984	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
22	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
23	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 990	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
24	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
25	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 996	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
26	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
27	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1001	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
28	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
29	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1007	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
30	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
31	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1013	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
32	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
33	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1019	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
34	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
35	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1025	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
36	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
37	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1031	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
38	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
39	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1037	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
40	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
41	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1043	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
42	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
43	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1049	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
44	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
45	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1055	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
46	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
47	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1061	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.
48	diff	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918	0.001 (s^-1)	0.001 (s^-1)	Keq = 1(uM)	500sec	Substrate CaM-GEF Product CaM-GEF
49	CaM-bind-GEF	Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84	Ras Pathway No. : 1067	199.995 (uM^-1 s^-1)	1 (s^-1)	Kd(bf) = 0.005(uM)	-	Substrate CaM-Ca4 inact-GEF Product CaM-GEF
	We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1.

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