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Molecule Parameter List for CaM-TR2-Ca2

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaM-TR2-Ca2 participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences2500004949

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_ReacDiff3
    		• 84NetworkShared_Object_Ajay_Bhalla_2007_ReacDiff3,  PKC,  PLA2,  
    MAPK,  PLA2,  Ras,  CaM,  chain,  kinetics,  PKC,  MAPK,  Ras,  CaM,  kinetics[1],  
    PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[2],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[3],  
    PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[4],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[5],  
    PKC,  PLA2,  MAPK,  Ras,  MAPK,  CaM,  kinetics[6],  PKC,  PLA2,  MAPK,  Ras,  
    CaM,  kinetics[7],  PKC,  PLA2,  MAPK,  Ras,  CaM,  PKC,  kinetics[8],  PLA2,  
    MAPK,  Ras,  CaM,  kinetics[9],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[10],  
    PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[11],  PKC,  PLA2,  MAPK,  Ras,  CaM,  
    kinetics[12],  PKC,  PLA2,  Ras,  CaM,  kinetics[13],  PKC,  PLA2,  MAPK,  
    Ras,  CaM,  kinetics[14],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[15],  
    PKC,  PLA2,  MAPK,  Ras,  kinetics[16],  CaM,  PKC,  PLA2,  MAPK,  Ras,  CaM,  
    kinetics[17],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[18],  PKC,  PLA2,  
    MAPK,  Ras,  CaM,  kinetics[19],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[20],  
    PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[21],  PKC,  PLA2,  MAPK,  Ras,  CaM,  
    kinetics[22],  PKC,  PLA2,  MAPK,  Ras,  CaM,  kinetics[23],  PKC,  PLA2,  
    MAPK,  Ras,  CaM 
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
    In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
    The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
    The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.

    CaM-TR2-Ca2 acting as a Molecule in      Ajay_Bhalla_2007_ReacDiff3 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 924    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 930    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 936    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 942    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 948    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 954    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 961    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 967    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 973    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 979    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 985    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 991    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 997    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1002    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1008    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1014    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1021    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1026    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1032    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1038    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1044    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1050    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1056    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1062    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
    CaM-TR2-Ca2
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1068    		0125.7No
    This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.

    CaM-TR2-Ca2 acting as a Substrate in a reaction in      Ajay_Bhalla_2007_ReacDiff3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 924    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    3
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 930    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    5
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 936    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    7
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 942    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    9
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 948    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    11
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 954    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    13
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 961    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    15
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 967    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    17
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 973    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    19
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 979    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    21
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 985    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    23
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 991    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    25
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 997    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    26diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    27
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1002    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    28diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    29
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1008    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    30diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    31
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1014    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    32diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    33
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1021    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    34diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    35
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1026    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    36diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    37
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1032    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    38diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    39
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1038    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    40diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    41
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1044    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    42diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    43
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1050    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    44diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    45
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1056    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    46diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    47
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1062    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10
    48diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    49
  • CaM-TR2-Ca2-bind
    -Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1068    		3.6
    (uM^-1 s^-1)    		10
    (s^-1)    		Kd(bf) = 2.7778(uM)-Substrate
    Ca
    CaM-TR2-Ca2

    Product
    CaM-Ca3
      K3 = 21.5, K4 = 2.8. Assuming that the K4 step happens first, we get kb/kf = 2.8 uM = 1.68e6 so kf =6e-6 assuming kb = 10

    CaM-TR2-Ca2 acting as a Product in a reaction in      Ajay_Bhalla_2007_ReacDiff3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 924    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    2diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    3CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 930    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    4diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    5CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 936    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    6diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    7CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 942    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    8diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    9CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 948    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    10diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    11CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 954    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    12diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    13CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 961    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    14diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    15CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 967    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    16diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    17CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 973    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    18diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    19CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 979    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    20diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    21CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 985    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    22diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    23CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 991    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    24diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    25CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 997    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    26diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    27CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1002    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    28diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    29CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1008    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    30diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    31CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1014    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    32diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    33CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1021    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    34diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    35CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1026    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    36diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    37CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1032    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    38diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    39CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1038    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    40diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    41CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1044    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    42diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    43CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1050    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    44diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    45CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1056    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    46diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    47CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1062    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....
    48diff
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3
    Pathway No. : 918
    		• 0.001
    (s^-1)    		0.001
    (s^-1)    		Keq = 1(uM)500secSubstrate
    CaM-TR2-Ca2

    Product
    CaM-TR2-Ca2
    49CaM-TR2-bind-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3
    Accession No. : 84
    		• CaM
    Pathway No. : 1068    		72.0006
    (uM^-2 s^-1)    		72
    (s^-1)    		Kd(af) = 1(uM)-Substrate
    Ca
    Ca
    CaM

    Product
    CaM-TR2-Ca2
      Lets use the fast rate consts here. Since the rates are so different, I am not sure whether the order is relevant. These correspond to the TR2C fragment. We use the Martin et al rates here, plus the Drabicowski binding consts. All are scaled by 3X to cell temp. kf = 2e-10 kb = 72 Stemmer & Klee: K1=.9, K2=1.1. Assume 1.0uM for both. kb/kf=3.6e11. If kb=72, kf = 2e-10 (Exactly the same !)....


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