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Molecule Parameter List for PIP2-Ca-PLA2* | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color. | Statistics | Accession and Pathway Details | |
Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_ 2007_ReacDiff3 | 84 | Network | Shared_Object_Ajay_Bhalla_2007_ReacDiff3, PKC, PLA2, MAPK, PLA2, Ras, CaM, chain, kinetics, PKC, MAPK, Ras, CaM, kinetics[1], PKC, PLA2, MAPK, Ras, CaM, kinetics[2], PKC, PLA2, MAPK, Ras, CaM, kinetics[3], PKC, PLA2, MAPK, Ras, CaM, kinetics[4], PKC, PLA2, MAPK, Ras, CaM, kinetics[5], PKC, PLA2, MAPK, Ras, MAPK, CaM, kinetics[6], PKC, PLA2, MAPK, Ras, CaM, kinetics[7], PKC, PLA2, MAPK, Ras, CaM, PKC, kinetics[8], PLA2, MAPK, Ras, CaM, kinetics[9], PKC, PLA2, MAPK, Ras, CaM, kinetics[10], PKC, PLA2, MAPK, Ras, CaM, kinetics[11], PKC, PLA2, MAPK, Ras, CaM, kinetics[12], PKC, PLA2, Ras, CaM, kinetics[13], PKC, PLA2, MAPK, Ras, CaM, kinetics[14], PKC, PLA2, MAPK, Ras, CaM, kinetics[15], PKC, PLA2, MAPK, Ras, kinetics[16], CaM, PKC, PLA2, MAPK, Ras, CaM, kinetics[17], PKC, PLA2, MAPK, Ras, CaM, kinetics[18], PKC, PLA2, MAPK, Ras, CaM, kinetics[19], PKC, PLA2, MAPK, Ras, CaM, kinetics[20], PKC, PLA2, MAPK, Ras, CaM, kinetics[21], PKC, PLA2, MAPK, Ras, CaM, kinetics[22], PKC, PLA2, MAPK, Ras, CaM, kinetics[23], PKC, PLA2, MAPK, Ras, CaM | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. |
PIP2-Ca-PLA2* acting as a Molecule in Ajay_Bhalla_2007_ReacDiff3 Network
PIP2-Ca-PLA2* acting as an Enzyme in Ajay_Bhalla_2007_ReacDiff3 Network
| Enzyme Molecule / Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | 1 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 920 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 2 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 922 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 3 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 933 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 4 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 939 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 5 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 945 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 6 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 951 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 7 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 957 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 8 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 964 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 9 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 970 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 10 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 976 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 11 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 982 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 12 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 988 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 13 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 994 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 14 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 1000 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 15 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 1005 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 16 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 1011 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 17 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 1017 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 18 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 1023 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 19 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 1029 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 20 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 1035 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 21 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 1041 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 22 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 1047 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 23 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 1053 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 24 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 1059 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. | 25 | PIP2-Ca-PLA2* / kenz
| Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | PLA2 Pathway No. : 1065 | 20 | 36 | 4 | explicit E-S complex | Substrate APC
Product AA
| | 10 x raise oct 22 12 x and rescale for k2 = 4 * k3 convention oct 24 Increase further to get the match to expt, which was spoilt due to large accumulation of PLA2 in the enzyme complexed forms. Lets raise k3, leaving the others at k1 = 1.5e-5 and k2 = 144 since they are large already. |
PIP2-Ca-PLA2* acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff3 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
PIP2-Ca-PLA2* acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff3 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details. |
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