DOQCS Database

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	Molecule Name/ Site Name	Km (uM)	kcat (1/s)	Ratio (k2/k3)	Enzyme Type	Substrate	Product
1	Enzyme Activity: dipp_ip7 Enzyme Molecule: DIPP1	0.34	5.1	4	explicit E-S complex	PP-IP5	IP6
	from Safrany et al, EMBO J 17(22); 1998 Vmax represents activity of recombinant human protein which is 20-50 fold greater than activity of the purified rat enzyme
2	Enzyme Activity: dipp_ip8 Enzyme Molecule: DIPP1	0.034	0.6165	4	explicit E-S complex	bisPP-IP4	PP-IP5
	from Safrany et al, EMBO J 17(22); 1998 Vmax represents activity of human recombinant protein, which is 20-50 fold greater than activity of the purified rat enzyme
3	Enzyme Activity: ip5_k1 Enzyme Molecule: IP6-K	6.7	0.234	4	explicit E-S complex	IP5(13456)	PP-IP4
	from Saiardi et al, JBC 275(32); 2000: 24686-92
4	Enzyme Activity: ip5_k2 Enzyme Molecule: IP6_K2	8.4	0.0572	4	explicit E-S complex	IP5(13456)	PP-IP4
	from Saiardi et al, JBC 275(32); 2000: 24686-92
5	Enzyme Activity: ip6_k2 Enzyme Molecule: IP6_K2	3	1.633	4	explicit E-S complex	IP6	PP-IP5
	from Saiardi et al, Curr Biol 9; 1999
6	Enzyme Activity: pp-ip4-k1 Enzyme Molecule: IP6-K	23.0003	0.05	4	explicit E-S complex	PP-IP4	bisPP-IP3
	from Saiardi et al, JBC 275; 2000 approx Km and Vmax calculated from first order rate constants
7	Enzyme Activity: pp-ip4-k2 Enzyme Molecule: IP6_K2	30.0003	0.01	4	explicit E-S complex	PP-IP4	bisPP-IP3
	from Saiardi et al, JBC 275; 2000 approx Km and Vmax calculated from first order rate constants

Enzyme List