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Reaction List for pathway Othmer-Tang-model (Pathway Number 133) |
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered. |
| Name | Kf | Kb | Kd | tau | Substrate | Product | |
| 1 | actIP3R | 1000.01 (uM^-2 s^-1) | 5 (s^-1) | Keq = 0.005(uM) | - | Ca.IP3.IP3R Ca.IP3.IP3R Ca.IP3.IP3R | activeIP3R |
| Rate set so that almost all Ca.IP3.IP3R complex (formed by Ca and IP3 binding to the IP3R) becomes the active Ca conducting channel | |||||||
| 2 | bind_act_Ca | 15 (uM^-1 s^-1) | 1.65 (s^-1) | Kd(bf) = 0.11(uM) | - | IP3.IP3R Ca | Ca.IP3.IP3R |
| from the O-T model in Tang et al, Biophys J 70, 1996 | |||||||
| 3 | bind_inact_Ca | 1.8001 (uM^-1 s^-1) | 0.21 (s^-1) | Kd(bf) = 0.1167(uM) | - | Ca.IP3.IP3R Ca | Ca2.IP3.IP3R |
| from the O-T model in Tang et al, Biophys J 70, 1996 | |||||||
| 4 | bind_IP3 | 12 (uM^-1 s^-1) | 8 (s^-1) | Kd(bf) = 0.6667(uM) | - | IP3R IP3 | IP3.IP3R |
| from the O-T model in Tang et al, Biophys J 70, 1996 | |||||||
| Pathway Detail | Molecule List | Enzyme List | Reaction List |