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Accession Type:
Network
AMPAR_CaMKII_
weak_coupling
Shared_Object_
AMPAR_CaMKII_
weak_coupling
CaMKII
CaM
PP1
PP2B
PP1_PSD
AMPAR
 Molecule
 Reaction
PKA
AC
AMPAR_memb
PP1_CaMKII_PSD
CaMKII_PSD

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Reaction List for pathway AMPAR (Pathway Number 287)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 degrade**0
(s^-1)		0
(s^-1)		--
  • A835*845*_
    B835*845*
    		• AMPAR_deg
    2 degrade*_0
    (s^-1)    		0
    (s^-1)    		--A831*845*_B845*
    		AMPAR_deg
    3 degrade_*0
    (s^-1)    		0
    (s^-1)    		--A845*_B831*845*
    		AMPAR_deg
    4 degrade__0
    (s^-1)    		0
    (s^-1)    		--A845*_B845*
    		AMPAR_deg
    5 exo_reg**0.0002
    (#^-1 s^-1)    		0.008
    (s^-1)    		Not applicable**-
  • A835*845*_
    B835*845*
    Anchor
  • A835*845*_
    B835*845*
    • 6 exo_reg*_0.0002
    (#^-1 s^-1)    		0.008
    (s^-1)    		Not applicable**-A831*845*_B845*
    Anchor
    		A831*845*_B845*
    7 exo_reg_*0.0002
    (#^-1 s^-1)    		0.008
    (s^-1)    		Not applicable**-A845*_B831*845*
    Anchor
    		A845*_B831*845*
    8 exo_reg__0.0002
    (#^-1 s^-1)    		0.008
    (s^-1)    		Not applicable**-A845*_B845*
    Anchor
    		A845*_B845*
      Exo rates are scaled from earlier model versions to account for binding of anchor. We have about 200 molecules of anchor in the whole model. Here we select rates to give us a max of about 150 molecules of GluR at the synapse.
    9 recycle**0.0008
    (s^-1)    		0
    (#^-1 s^-1)    		Not applicable**-A831*_B831*
    		A831*_B831*
    Anchor
    10 recycle*_0.0008
    (s^-1)    		0
    (#^-1 s^-1)    		Not applicable**-A831*_B
    		A831*_B
    Anchor
    11 recycle_*0.0008
    (s^-1)    		0
    (#^-1 s^-1)    		Not applicable**-A_B831*
    		A_B831*
    Anchor
    12 recycle__0.0008
    (s^-1)    		0
    (#^-1 s^-1)    		Not applicable**-A_B
    		A_B
    Anchor
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration.


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    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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