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Accession Type:
Network
fig2_egfr
Shared_Object_
fig2_egfr
PKC
PLA2
PLCbeta
Gq
MAPK
Ras
EGFR
Sos
 Molecule
 Reaction
PLC_g
CaRegulation

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Reaction List for pathway Sos (Pathway Number 9)

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reactions is not considered.
  Name KfKbKdtauSubstrateProduct
1 dephosph_Sos0.001
(s^-1)		0
(s^-1)		--Sos*
Sos
2 Grb2_bind_Sos0.025
(uM^-1 s^-1)		0.0168
(s^-1)		Kd(bf) = 0.672(uM)-Grb2
Sos
Sos.Grb2
3 Grb2_bind_Sos*0.025
(uM^-1 s^-1)		0.0168
(s^-1)		Kd(bf) = 0.672(uM)-Sos*
Grb2
Sos*.Grb2
4 Shc_bind_
Sos.Grb2		0.5
(uM^-1 s^-1)		0.1
(s^-1)		Kd(bf) = 0.2(uM)-Sos.Grb2
SHC*
Shc*.Sos.Grb2


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Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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