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Accession Type:
Network
Ajay_Bhalla_
2007_Bistable
Shared_Object_
Ajay_Bhalla_
2007_Bistable
PKC
PLA2
MAPK
Ras
CaM
 Molecule
 Reaction

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Parameters for CaM (Pathway Number 368)

Pathway Layout

Pathway Basic Parameters

Pathway NameCaM
Pathway Entry Number 368
Accession Number 79
Accession Name Ajay_Bhalla_2007_Bistable
Species Rat
Tissue Hippocampal CA1
CellCompartmentDendrite
Related Pathways 14, 27, 81, 107, 122, 146, 160, 173, 203, 217, 236, 246, 259, 265, 273, 283, 323, 340, 358, 373, 379, 386, 392, 398, 405, 411, 418, 423, 428, 434, 440, 446, 452, 458, 464, 470, 476, 482, 488, 494, 500, 506, 512, 518, 524, 530, 537, 543, 549, 555, 561, 568, 573, 579, 585, 591, 597, 603, 609, 615, 621, 627, 633, 639, 645, 651, 657, 663, 669, 675, 681, 688, 695, 701, 706, 712, 718, 724, 730, 736, 742, 748, 754, 760, 766, 772, 778, 784, 790, 796, 802, 808, 814, 820, 826, 832, 838, 844, 850, 856, 862, 868, 874, 880, 886, 892, 898, 904, 910, 916, 924, 930, 936, 942, 948, 954, 961, 967, 973, 979, 985, 991, 997, 1002, 1008, 1014, 1021, 1026, 1032, 1038, 1044, 1050, 1056, 1062, 1068, 1094
Notes  This is a model of ERKII signaling which is bistable due to feedback. The feedback occurs through ERKII phosphorylation of phospholipase A2 (PLA2), leading to increased production of arachidonic acid (AA), which activates protein kinase C (PKC) which activates c-Raf which is upstream of ERKII.
The model is a highly simplified variant of more detailed bistable models of MAPK signaling (Bhalla US, Iyengar R. Science. 1999 Jan 15;283(5400):381-7, Ajay SM, Bhalla US. Eur J Neurosci. 2004 Nov;20(10):2671-80)

Statistics

Enzyme sites
4
0
3

Conversion format

This pathway is part of accession 79 and is completely specified in the file acc79.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc79.g   
MATLAB format    acc79.m   
SBML format    acc79.xml   


Pathway Detail   Molecule List  Enzyme List   Reaction List  

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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