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Result: 1 - 14 of 14 rows are displayed

Reaction List for pathway CaMKII (Pathway Number 174) in Accession CaMKII (Accession Number 33)

Entries are grouped according to Pathway Number and they are alternately color coded using  and  color.
Further ordering can be done to the table header.  indicates that ordering is done according to ascending or descending order.
Keq is calculated only for first order reactions.
Kd is calculated only for second order reactions. [nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules]
  Reaction
Name
Pathway Name / 
Pathway No.
KfKbKdtauReagents
1 
  • CaMKII-CaMCa-bin
    d-Ca
  • CaMKII

    Pathway No. 174
    100.004
    (uM^-1 s^-1)
    20
    (s^-1)
    Kd(bf) = 0.2(uM)-  Substrate:
     CAMKII-CaMCa
     Ca

     Products:
     CaMKII-CaMCa2
    2 CaMKII-bind-CaMCaMKII

    Pathway No. 174
    0.2
    (uM^-1 s^-1)
    2700
    (s^-1)
    Kd(bf) = 13500(uM)-  Substrate:
     CaM
     CaMKII

     Products:
     CaMKII-CaM
    3 
  • CaMKII-bind-CaMC
    a
  • CaMKII

    Pathway No. 174
    0.8
    (uM^-1 s^-1)
    2700
    (s^-1)
    Kd(bf) = 3375.0084(uM)-  Substrate:
     CaMCa
     CaMKII

     Products:
     CAMKII-CaMCa
    4 
  • CaMKII-bind-CaMC
    a2
  • CaMKII

    Pathway No. 174
    2
    (uM^-1 s^-1)
    2250
    (s^-1)
    Kd(bf) = 1125(uM)-  Substrate:
     CaMCa2
     CaMKII

     Products:
     CaMKII-CaMCa2
    5 
  • CaMKII-bind-CaMC
    a3
  • CaMKII

    Pathway No. 174
    100.004
    (uM^-1 s^-1)
    22.5
    (s^-1)
    Kd(bf) = 0.225(uM)-  Substrate:
     CaMCa3
     CaMKII

     Products:
     CaMKII-CaMCa3
    6 
  • CaMKII-CaMCa2-bi
    nd-Ca
  • CaMKII

    Pathway No. 174
    100.004
    (uM^-1 s^-1)
    2
    (s^-1)
    Kd(bf) = 0.02(uM)-  Substrate:
     CaMKII-CaMCa2
     Ca

     Products:
     CaMKII-CaMCa3
    7 
  • CaMKII-CaMCa3-bi
    nd-Ca
  • CaMKII

    Pathway No. 174
    100.004
    (uM^-1 s^-1)
    100
    (s^-1)
    Kd(bf) = 1(uM)-  Substrate:
     CaMKII-CaMCa3
     Ca

     Products:
     CaMKII-CaMCa4
    8 
  • CaMKII-bind-CaMC
    a4
  • CaMKII

    Pathway No. 174
    100.004
    (uM^-1 s^-1)
    4.5
    (s^-1)
    Kd(bf) = 0.045(uM)-  Substrate:
     CaMCa4
     CaMKII

     Products:
     CaMKII-CaMCa4
    9 
  • CaMKII-CaM-bind-
    Ca
  • CaMKII

    Pathway No. 174
    4
    (uM^-1 s^-1)
    20
    (s^-1)
    Kd(bf) = 5(uM)-  Substrate:
     CaMKII-CaM
     Ca

     Products:
     CAMKII-CaMCa
    10 
  • Dephosph_
    trapped_T286
  • CaMKII

    Pathway No. 174
    0.003
    (s^-1)
    0
    (s^-1)
    --  Substrate:
     Trapped-T286

     Products:
     CaMKII-CaMCa4
      This rate is for the back reaction for the step represented here as a separate enzyme, but by Holmes as a single reversible reaction. Here it is treated as separate because the forward reaction is dependent on activity levels of the CaMKII, whereas the back reaction is not. Holmes tries a range of values for this back-reaction and says that it doesn't matter much.
    11 dephosph_T286CaMKII

    Pathway No. 174
    0.003
    (s^-1)
    0
    (s^-1)
    --  Substrate:
     Autonomous

     Products:
     CaMKII
    12 
  • Autonomous_
    lose_CaMCa4
  • CaMKII

    Pathway No. 174
    0.02
    (s^-1)
    0
    (uM^-1 s^-1)
    --  Substrate:
     Trapped-T286

     Products:
     Autonomous
     CaMCa4
      Holmes says that this rate is variable, and depends on Ca conc. It is 0.1 when [Ca] = 10 nM, and 0.00355/sec when [Ca] is 1.0 For our purposes, we assume a good steady approx to this rate is 0.02.
    13 
  • Autonomous-bind-
    CaMCa4
  • CaMKII

    Pathway No. 174
    33.2998
    (uM^-1 s^-1)
    0
    (s^-1)
    --  Substrate:
     CaMCa4
     Autonomous

     Products:
     Trapped-T286
    14 dephosph_T305CaMKII

    Pathway No. 174
    0.01
    (s^-1)
    0
    (s^-1)
    --  Substrate:
     Capped

     Products:
     Autonomous
      This is treated as a separate reaction because it is independent of the CaMKII concentration or activation state, unlike the forward reaction in the Holmes paper. Holmes tries a range of rates for this step, and says it doesn't matter much.

     
    Result: 1 - 14 of 14 rows are displayed



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