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Molecule Parameter List for CaN

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*CaN* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	0	0	0	0	5	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
CaMKII	33	Network	Shared_Object_CaMKII, CaM, CaMKII, CaN
This is a deterministic, point kinetics approximation to the dendritic spine CaMKII model described in William R. Holmes J Comput Neurosci. (2000) 8(1):65-85. Rates are the same but the responses differ somewhat because this model does not include the stochastic and diffusive calculations of the original.

CaN acting as a Molecule in CaMKII Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaN	CaMKII Accession No. : 33	CaN Pathway No. : 175	3.6415	0.1309	No
Holmes assumes that there are 286 calcinuerin molecules.

CaN acting as a Substrate in a reaction in CaMKII Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	CaN-bind-CaM	CaMKII Accession No. : 33	CaN Pathway No. : 175	0.2 (uM^-1 s^-1)	5000 (s^-1)	Kd(bf) = 25000(uM)	-	Substrate CaM CaN Product CaN-CaM
2	CaN-bind-CaMCa	CaMKII Accession No. : 33	CaN Pathway No. : 175	5 (uM^-1 s^-1)	3750 (s^-1)	Kd(bf) = 749.9955(uM)	-	Substrate CaMCa CaN Product CaN-CaMCa
3	CaN-bind-CaMCa2	CaMKII Accession No. : 33	CaN Pathway No. : 175	10.0004 (uM^-1 s^-1)	1250 (s^-1)	Kd(bf) = 124.995(uM)	-	Substrate CaMCa2 CaN Product CaN-CaMCa2
4	CaN-bind-CaMCa3	CaMKII Accession No. : 33	CaN Pathway No. : 175	100.004 (uM^-1 s^-1)	10 (s^-1)	Kd(bf) = 0.1(uM)	-	Substrate CaMCa3 CaN Product CaN-CaMCa3
5	CaN-bind-CaMCa4	CaMKII Accession No. : 33	CaN Pathway No. : 175	100.004 (uM^-1 s^-1)	0.6 (s^-1)	Kd(bf) = 0.006(uM)	-	Substrate CaMCa4 CaN Product CaN-CaMCa4

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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