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Molecule Parameter List for tot_MAPK

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
tot_MAPK participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1100000

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • mkp1_feedback_
    effects
    		• 4Network
    Shared_Object_mkp1_feedback_effects,  Sos,  PKC,  
    MAPK,  PLA2,  Ras,  
    PDGFR 
    This is a network involving the MAPK-PKC feedback loop with input from the PDGFR in the synapse. The distinctive feature of this model is that it includes MKP-1 induction by MAPK, and the consequent inhibitory regulation of MAPK and the feedback loop. Lots of interesting dynamics arise from this. This link provides supplementary material for the paper Bhalla US et al. Science (2002) 297(5583):1018-23. In the form of several example simulations and demos for the figures in the paper.

    tot_MAPK acting as a Molecule in      mkp1_feedback_effects Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    tot_MAPK
  • mkp1_feedback_
    effects
    Accession No. : 4
  • Shared_Object_
    mkp1_feedback_
    effects
    Pathway No. : 32
    		• 01000No
    Total available active MAPK. This sums the levels of the cytosolic and nuclear localized forms.

    tot_MAPK acting as a Summed Molecule in      mkp1_feedback_effects Network
    Accession NamePathway NameTargetInput
  • mkp1_feedback_
    effects
    Accession No. : 4
  • Shared_Object_
    mkp1_feedback_
    effects
    Pathway No. : 32
    		• tot_MAPKMAPK*
    nuc_MAPK*
    Total available active MAPK. This sums the levels of the cytosolic and nuclear localized forms.


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.