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Molecule Parameter List for MAPK

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
MAPK participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1001100

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

MAPK acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
MAPKfig2_egfr
Accession No. : 1
MAPK
Pathway No. : 6
0.361000No

MAPK acting as a Substrate for an Enzyme in  
fig2_egfr Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
MAPKK*  /
MAPKKtyr
fig2_egfr
Accession No. : 1
MAPK
Pathway No. : 6
0.04629630.154explicit E-S complexSubstrate
MAPK

Product
MAPK-tyr

MAPK acting as a Product of an Enzyme in  
fig2_egfr Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
MKP-1  /
MKP1-tyr-deph
fig2_egfr
Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 0.066666714explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.