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Molecule Parameter List for MAPK-tyr

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
MAPK-tyr participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1002200

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

MAPK-tyr acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
MAPK-tyrfig2_egfr
Accession No. : 1
MAPK
Pathway No. : 6
01000No

MAPK-tyr acting as a Substrate for an Enzyme in  
fig2_egfr Network
 Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
1MAPKK*  /
MAPKKthr
fig2_egfr
Accession No. : 1
MAPK
Pathway No. : 6
0.04629630.154explicit E-S complexSubstrate
MAPK-tyr

Product
MAPK*
2MKP-1  /
MKP1-tyr-deph
fig2_egfr
Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 0.066666714explicit E-S complexSubstrate
    MAPK-tyr

    Product
    MAPK

    MAPK-tyr acting as a Product of an Enzyme in  
    fig2_egfr Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1MAPKK*  /
    MAPKKtyr
    fig2_egfr
    Accession No. : 1
    MAPK
    Pathway No. : 6
    0.04629630.154explicit E-S complexSubstrate
    MAPK

    Product
    MAPK-tyr
    2MKP-1  /
    MKP1-thr-deph
    fig2_egfr
    Accession No. : 1
  • Shared_Object_
    fig2_egfr

    Pathway No. : 1
  • 0.066666714explicit E-S complexSubstrate
    MAPK*

    Product
    MAPK-tyr



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.