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Molecule Parameter List for PKC-Ca

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PKC-Ca participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences2500009949

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Ajay_Bhalla_
    2007_ReacDiff3
  • 84NetworkShared_Object_Ajay_Bhalla_2007_ReacDiff3 PKC PLA2 
    MAPK PLA2 Ras CaM chain kinetics PKC MAPK Ras CaM kinetics[1] 
    PKC PLA2 MAPK Ras CaM kinetics[2] PKC PLA2 MAPK Ras CaM kinetics[3] 
    PKC PLA2 MAPK Ras CaM kinetics[4] PKC PLA2 MAPK Ras CaM kinetics[5] 
    PKC PLA2 MAPK Ras MAPK CaM kinetics[6] PKC PLA2 MAPK Ras 
    CaM kinetics[7] PKC PLA2 MAPK Ras CaM PKC kinetics[8] PLA2 
    MAPK Ras CaM kinetics[9] PKC PLA2 MAPK Ras CaM kinetics[10] 
    PKC PLA2 MAPK Ras CaM kinetics[11] PKC PLA2 MAPK Ras CaM 
    kinetics[12] PKC PLA2 Ras CaM kinetics[13] PKC PLA2 MAPK 
    Ras CaM kinetics[14] PKC PLA2 MAPK Ras CaM kinetics[15] 
    PKC PLA2 MAPK Ras kinetics[16] CaM PKC PLA2 MAPK Ras CaM 
    kinetics[17] PKC PLA2 MAPK Ras CaM kinetics[18] PKC PLA2 
    MAPK Ras CaM kinetics[19] PKC PLA2 MAPK Ras CaM kinetics[20] 
    PKC PLA2 MAPK Ras CaM kinetics[21] PKC PLA2 MAPK Ras CaM 
    kinetics[22] PKC PLA2 MAPK Ras CaM kinetics[23] PKC PLA2 
    MAPK Ras CaM 
    This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
    In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
    The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
    The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper.

    PKC-Ca acting as a Molecule in  
    Ajay_Bhalla_2007_ReacDiff3 Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 919
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 927
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 932
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 938
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 944
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 950
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 956
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 963
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 969
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 974
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 981
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 987
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 993
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 999
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1004
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1010
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1016
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1022
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1028
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1034
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1040
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1046
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1052
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1058
    0125.7No
    PKC-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1064
    0125.7No

    PKC-Ca acting as a Substrate in a reaction in  
    Ajay_Bhalla_2007_ReacDiff3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    2PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 919
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    3PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 919
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    4
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 919
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    6PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 927
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    7PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 927
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    8
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 927
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    10PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 932
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    11PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 932
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    12
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 932
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    14PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 938
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    15PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 938
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    16
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 938
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    18PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 944
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    19PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 944
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    20
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 944
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    22PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 950
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    23PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 950
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    24
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 950
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    25diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    26PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 956
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    27PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 956
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    28
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 956
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    29diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    30PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 963
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    31PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 963
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    32
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 963
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    33diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    34PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 969
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    35PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 969
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    36
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 969
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    37diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    38PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 974
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    39PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 974
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    40
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 974
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    41diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    42PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 981
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    43PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 981
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    44
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 981
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    45diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    46PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 987
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    47PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 987
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    48
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 987
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    49diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    50PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 993
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    51PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 993
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    52
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 993
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    53diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    54PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 999
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    55PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 999
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    56
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 999
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    57diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    58PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1004
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    59PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1004
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    60
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1004
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    61diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    62PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1010
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    63PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1010
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    64
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1010
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    65diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    66PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1016
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    67PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1016
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    68
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1016
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    69diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    70PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1022
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    71PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1022
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    72
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1022
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    73diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    74PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1028
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    75PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1028
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    76
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1028
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    77diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    78PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1034
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    79PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1034
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    80
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1034
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    81diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    82PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1040
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    83PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1040
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    84
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1040
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    85diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    86PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1046
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    87PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1046
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    88
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1046
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    89diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    90PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1052
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    91PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1052
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    92
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1052
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    93diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    94PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1058
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    95PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1058
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    96
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1058
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.
    97PKC-act-by-DAG
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1064
    0.008
    (uM^-1 s^-1)
    8.6348
    (s^-1)
    Kd(bf) = 1079.4148(uM)-Substrate
    DAG
    PKC-Ca

    Product
    PKC-Ca-DAG
      Need est of rate. Assume it is fast Obtained from param search kf raised 10 X : see Shinomura et al PNAS 88 5149-5153 1991. kf changed from 3.865e-7 to 2.0e-7 in line with closer analysis of Shinomura data. 26 June 1996: Corrected DAG data: reduce kf 15x from 2e-7 to 1.333e-8
    98PKC-Ca-to-memb
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1064
    1.2705
    (s^-1)
    3.5026
    (s^-1)
    Keq = 2.7569(uM)0.21secSubstrate
    PKC-Ca

    Product
    PKC-Ca-memb*
    99
  • PKC-act-by-Ca-AA
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1064
    0.0012
    (uM^-1 s^-1)
    0.1
    (s^-1)
    Kd(bf) = 83.3333(uM)-Substrate
    AA
    PKC-Ca

    Product
    PKC-Ca-AA*
      Schaechter and Benowitz We have to increase Kf for conc scaling Changed kf to 2e-9 on Sept 19, 94. This gives better match.

    PKC-Ca acting as a Product in a reaction in  
    Ajay_Bhalla_2007_ReacDiff3 Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    2PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 919
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    3diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    4PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 927
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    5diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    6PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 932
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    7diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    8PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 938
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    9diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    10PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 944
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    11diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    12PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 950
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    13diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    14PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 956
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    15diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    16PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 963
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    17diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    18PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 969
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    19diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    20PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 974
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    21diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    22PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 981
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    23diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    24PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 987
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    25diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    26PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 993
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    27diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    28PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 999
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    29diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    30PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1004
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    31diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    32PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1010
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    33diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    34PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1016
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    35diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    36PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1022
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    37diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    38PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1028
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    39diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    40PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1034
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    41diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    42PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1040
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    43diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    44PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1046
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    45diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    46PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1052
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    47diff
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • Shared_Object_
    Ajay_Bhalla_
    2007_ReacDiff3

    Pathway No. : 918
  • 0.001
    (s^-1)
    0.001
    (s^-1)
    Keq = 1(uM)500secSubstrate
    PKC-Ca

    Product
    PKC-Ca
    48PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1058
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5
    49PKC-act-by-Ca
  • Ajay_Bhalla_
    2007_ReacDiff3

    Accession No. : 84
  • PKC
    Pathway No. : 1064
    0.6
    (uM^-1 s^-1)
    0.5
    (s^-1)
    Kd(bf) = 0.8333(uM)-Substrate
    Ca
    PKC-cytosolic

    Product
    PKC-Ca
      Need est of rate of assoc of Ca and PKC. Assume it is fast The original parameter-searched kf of 439.4 has been scaled by 1/6e8 to account for change of units to n. Kf now 8.16e-7, kb=.6085 Raised kf to 1e-6 to match Ca curve, kb to .5



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