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Molecule List for Accession CaMKII_noPKA_model3 (Accession Number62)

Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.

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The entries are grouped according to Pathway Number and are alternately color coded using

and

color.

	Name	Pathway Name / Pathway No.	Accession Type	Initial Conc. (uM)	Volume (fL)	Buffered	Sum Total Of
1	286P-PSD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0	0.01	No	CaMKII-thr286-Ca M-PSD CaMKII-thr286-PS D
2	actCaMKII-PSD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	2	0.01	No	CaMKII-thr286-Ca M-PSD CaMKII-CaM-PSD tot-auto-PSD
3	act_CaMKII_cyt	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	2	0.09	No	tot_CaM_CaMKII tot_autonomous_ CaMKII
4	basal_CaMKII_ cyt	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	2	0.09	Yes	-
5	basal_CaMKII_ PSD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	2	0.01	No	-
6	basal_CaMKII_ PSD_control	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	2	0.01	Yes	-
7	Ca	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0.08	0.09	No	-
8	Ca-PSD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0.08	0.01	No	-
9	CaM	CaM Pathway No. 259	Network	26.3333	0.09	No	-
	There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
10	CaM-Ca3	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0	0.09	No	-
11	CaM-Ca3-PSD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0.0025	0.01	No	-
12	CaM-Ca4	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0	0.09	No	-
13	CaM-Ca4-PSD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0	0.01	No	-
14	CaM-PSD	CaM Pathway No. 259	Network	26.3333	0.01	No	-
	There is a LOT of this in the cell: upto 1% of total protein mass. (Alberts et al) Say 25 uM. Meyer et al Science 256 1199-1202 1992 refer to studies saying it is comparable to CaMK levels.
15	CaM-TR2-Ca2	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0	0.09	No	-
	This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
16	CaM-TR2-Ca2-PSD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0	0.01	No	-
	This is the intermediate where the TR2 end (the high-affinity end) has bound the Ca but the TR1 end has not.
17	CaMK-thr305	CaMKII Pathway No. 258	Network	0	0.09	No	-
	This forms due to basal autophosphorylation, but I think it has to be considered as a pathway even if some CaM is floating around. In either case it will tend to block further binding of CaM, and will not display any enzyme activity. See Hanson and Schulman JBC 267:24 pp17216-17224 1992
18	CaMKII	CaMKII Pathway No. 258	Network	20	0.09	No	-
	Huge conc of CaMKII. In PSD it is 20-40% of protein, so we assume it is around 2.5% of protein in spine as a whole. This level is so high it is unlikely to matter much if we are off a bit.
19	CaMKII***	CaMKII Pathway No. 258	Network	0	0.09	No	-
	From Hanson and Schulman, the CaMKII does a lot of autophosphorylation just after the CaM is released. This prevents further CaM binding and renders the enzyme quite independent of Ca.
20	CaMKII***-PSD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0	0.01	No	-

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