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Molecule List for Accession CaMKII_noPKA_model3 (Accession Number62)

Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.

arrow indicates that ordering is done according to ascending or descending order.
The entries are grouped according to Pathway Number and are alternately color coded using

and

color.

	Name	Pathway Name / Pathway No.	Accession Type	Initial Conc. (uM)	Volume (fL)	Buffered	Sum Total Of
1	tot_CaM_CaMKII	CaMKII Pathway No. 258	Network	0	0.09	No	CaMKII-CaM CaMKII-thr286*-C aM
2	tot_CaMKII_PSD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	2	0.01	No	actCaMKII-PSD CaMKII-PSD CaMKII-thr305-PS D
3	tot_CaMKII_cyt	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	22	0.09	No	CaMKII-CaM CaMKII-thr286-C aM CaMKII-thr286 CaMKII** CaMK-thr305 CaMKII basal_CaMKII_ cyt
4	tot_autonomous_ CaMKII	CaMKII Pathway No. 258	Network	2	0.09	No	CaMKII-thr286 CaMKII*** basal_CaMKII_ cyt
5	tot-CaM-CaMKII-P SD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0	0.01	No	CaMKII-thr286-Ca M-PSD CaMKII-CaM-PSD
6	tot-auto-PSD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	2	0.01	No	CaMKII-thr286-PS D CaMKII***-PSD basal_CaMKII_ PSD
7	PP2A	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0.1111	0.09	No	-
8	PP1-I1*	PP1 Pathway No. 260	Network	0	0.09	No	-
9	PP1-I1*	PP1_PSD Pathway No. 262	Network	0	0.01	No	-
10	PP1-I1	PP1 Pathway No. 260	Network	0	0.09	No	-
11	PP1-I1	PP1_PSD Pathway No. 262	Network	0	0.01	No	-
12	PP1-active_PSD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	4	0.01	No	-
	Cohen et al Meth Enz 159 390-408 is main source of info conc = 1.8 uM
13	PP1-active	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	1.8	0.09	No	-
	Cohen et al Meth Enz 159 390-408 is main source of info conc = 1.8 uM
14	PKA-active	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0.0185	0.09	No	-
15	NMDAR	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	120	0.01	No	-
	The stochiometry is a bit off here. Each NMDAR actually binds to a holoenzyme, about 12 CaMKII subunits. But our CaMKII calculations are in terms of individual subunits. So as a hack, we put in much more NMDAR than is actually there.
16	I1*	PP1 Pathway No. 260	Network	0	0.09	No	-
	Dephosph is mainly by PP2B
17	I1*	PP1_PSD Pathway No. 262	Network	0	0.01	No	-
	Dephosph is mainly by PP2B
18	I1	PP1 Pathway No. 260	Network	1.8	0.09	No	-
	I1 is a 'mixed' inhibitor, but at high enz concs it looks like a non-compet inhibitor (Foulkes et al Eur J Biochem 132 309-313 9183). We treat it as non-compet, so it just turns the enz off without interacting with the binding site. Cohen et al ann rev bioch refer to results where conc is 1.5 to 1.8 uM. In order to get complete inhib of PP1, which is at 1.8 uM, we need >= 1.8 uM.
19	I1	PP1_PSD Pathway No. 262	Network	4	0.01	No	-
	I1 is a 'mixed' inhibitor, but at high enz concs it looks like a non-compet inhibitor (Foulkes et al Eur J Biochem 132 309-313 9183). We treat it as non-compet, so it just turns the enz off without interacting with the binding site. Cohen et al ann rev bioch refer to results where conc is 1.5 to 1.8 uM. In order to get complete inhib of PP1, which is at 1.8 uM, we need >= 1.8 uM.
20	Ca_control_PSD	Shared_Object_ CaMKII_noPKA_ model3 Pathway No. 257	Network	0.08	0.01	Yes	-

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