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Molecule List for Accession fig3_CaMKII (Accession Number2) | Default ordering is done according to Pathway Number. Table headers can be used for changing the default ordering.
  arrow indicates that ordering is done according to ascending or descending order.
The entries are grouped according to Pathway Number and are alternately color coded using  and  color. |
| |
Name | Pathway Name /
Pathway No. | Accession
Type | Initial
Conc.
(uM) | Volume
(fL) | Buffered | Sum Total Of | | 1 | tot_PP1 | Shared_Object_
fig3_CaMKII
Pathway No. 12Network | 0 | 1000 | No | PP1-active
| | | | tot_PP1 has inputs from Deph-thr286, PP1-active, Deph-thr305, Deph-thr286c, Deph-thr286b,Deph-thr305.
except PP1-active all other inputs are enzyme-substrate complex which is not currently supported by doqcs.
But can be accessed from GENESIS file.
| | 2 | tot_CaN-active | Shared_Object_
fig3_CaMKII
Pathway No. 12Network | 0 | 1000 | No | CaM(Ca)n-CaNAB
CaNAB-Ca4
| | 3 | tot_CaM_CaMKII | CaMKII
Pathway No. 13 | Network | 0 | 1000 | No | CaMKII-CaM
CaMKII-thr286*-C
aM
| | 4 | tot_
CaMKII-active | Shared_Object_
fig3_CaMKII
Pathway No. 12Network | 0 | 1000 | No | tot_CaM_CaMKII
tot_autonomous_
CaMKII
| | 5 | tot_autonomous_
CaMKII | CaMKII
Pathway No. 13 | Network | 0 | 1000 | No | CaMKII-thr286
CaMKII***
| | 6 | total-CaMKII | CaMKII
Pathway No. 13 | Network | 70 | 1000 | Yes | - | | 7 | R2C2-cAMP4 | PKA
Pathway No. 17 | Network | 0 | 1000 | No | - | | | R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with 4 cAMP molecules bound to it. All the regulatory subunits now have cAMP bound. This state is ready to dissociate and to release the catalytic subunit. | | 8 | R2C2-cAMP3 | PKA
Pathway No. 17 | Network | 0 | 1000 | No | - | | | R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with 3 cAMP molecules bound to it. | | 9 | R2C2-cAMP2 | PKA
Pathway No. 17 | Network | 0 | 1000 | No | - | | | R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with one molecule of cAMP bound to each of the B sites on the regulatory subunit. | | 10 | R2C2-cAMP | PKA
Pathway No. 17 | Network | 0 | 1000 | No | - | | | R2C2 complex consisting of 2 catalytic (C) subunits, and the R-dimer with one molecule of cAMP bound to site B1 on the regulatory subunit. | | 11 | R2C2 | PKA
Pathway No. 17 | Network | 0.5 | 1000 | No | - | | | PKA: Protein kinase activated by cAMP.
R2C2 complex consists of 2 catalytic (C) subunits, and the R-dimer. There are two types of cAMP binding sites termed A and B according to the rate with which they exchange bound labelled nucleotide.
Dagfinn Ogreid and Stein Ove Doskeland (1981) Int.J.Biochem. 13(1):1-19
Physiological concentration of PKA = 0.59 uM (cardiac myocyte)
Jeffrey J. Saucerman et al (2003) J.Biol.Chem. 278(48):47997-48003
| | 12 | R2C-cAMP4 | PKA
Pathway No. 17 | Network | 0 | 1000 | No | - | | | R2C1 complex consisting of 1 catalytic (C) subunit, and the R-dimer with 4 cAMP molecules bound to it. | | 13 | R2-cAMP4 | PKA
Pathway No. 17 | Network | 0 | 1000 | No | - | | | R-dimer is bound to 4 cAMP molecules. | | 14 | PP2A | Shared_Object_
fig3_CaMKII
Pathway No. 12Network | 0.12 | 1000 | No | - | | 15 | PP1-I1* | PP1
Pathway No. 15 | Network | 0 | 1000 | No | - | | 16 | PP1-I1 | PP1
Pathway No. 15 | Network | 0 | 1000 | No | - | | 17 | PP1-active | Shared_Object_
fig3_CaMKII
Pathway No. 12Network | 1.8 | 1000 | No | - | | 18 | PKC-active | Shared_Object_
fig3_CaMKII
Pathway No. 12Network | 0.09 | 1000 | Yes | - | | 19 | PKA-inhibitor | PKA
Pathway No. 17 | Network | 0.25 | 1000 | No | - | | 20 | PKA-active | Shared_Object_
fig3_CaMKII
Pathway No. 12Network | 0 | 1000 | No | - | | | | | | |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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