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Molecule Parameter List for G*GDP

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
G*GDP participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000012

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr,  PKC,  PLA2,  
PLCbeta,  Gq,  MAPK,  
Ras,  EGFR,  Sos,  
PLC_g,  CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

G*GDP acting as a Molecule in  fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)		Volume
(fL)		Buffered
G*GDPfig2_egfr
Accession No. : 1
  • Shared_Object_
    fig2_egfr
    Pathway No. : 1
    		• 01000No

    G*GDP acting as a Substrate in a reaction in      fig2_egfr Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    Trimerize-Gfig2_egfr
    Accession No. : 1    		Gq
    Pathway No. : 5    		6
    (uM^-1 s^-1)    		0
    (s^-1)    		--Substrate
    BetaGamma
    G*GDP

    Product
    G-GDP

    G*GDP acting as a Product in a reaction in      fig2_egfr Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1Inact-PLC-Gqfig2_egfr
    Accession No. : 1    		PLCbeta
    Pathway No. : 4    		0.0133
    (s^-1)    		0
    (uM^-1 s^-1)    		--Substrate
    PLC-Ca-Gq

    Product
    G*GDP
    PLC-Ca
    2Inact-Gfig2_egfr
    Accession No. : 1    		Gq
    Pathway No. : 5    		0.0133
    (s^-1)    		0
    (s^-1)    		--Substrate
    G*GTP

    Product
    G*GDP


    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
    This Copyright is applied to ensure that the contents of this database remain freely available. Please see FAQ for details.