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Molecule Parameter List for PKC-active

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by

color.

Statistics

*PKC-active* participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	1	3	0	0	0	0

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
fig2_egfr	1	Network	Shared_Object_fig2_egfr, PKC, PLA2, PLCbeta, Gq, MAPK, Ras, EGFR, Sos, PLC_g, CaRegulation
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse. Demonstration script files for generating the figures in the paper, including figure 2, are available here.

PKC-active acting as a Molecule in fig2_egfr Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
PKC-active	fig2_egfr Accession No. : 1	Shared_Object_ fig2_egfr Pathway No. : 1	0.02	1000	No

PKC-active acting as a Summed Molecule in fig2_egfr Network

Accession Name	Pathway Name	Target	Input
fig2_egfr Accession No. : 1	Shared_Object_ fig2_egfr Pathway No. : 1	PKC-active	PKC-DAG-AA* PKC-Ca-memb* PKC-Ca-AA* PKC-DAG-memb* PKC-basal* PKC-AA*

PKC-active acting as an Enzyme in fig2_egfr Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	PKC-active / PKC-act-raf	fig2_egfr Accession No. : 1	Shared_Object_ fig2_egfr Pathway No. : 1	66.6667	4	4	explicit E-S complex	Substrate craf-1 Product craf-1*
2	PKC-active / PKC-inact-GAP	fig2_egfr Accession No. : 1	Shared_Object_ fig2_egfr Pathway No. : 1	3.33333	4	4	explicit E-S complex	Substrate GAP Product GAP*
3	PKC-active / PKC-act-GEF	fig2_egfr Accession No. : 1	Shared_Object_ fig2_egfr Pathway No. : 1	3.33333	4	4	explicit E-S complex	Substrate inact-GEF Product GEF*

Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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