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Molecule Parameter List for inact_cap_entry | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
| inact_cap_entry participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction | | No. of occurrences | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Synaptic_
Network | 16 | Network |
Shared_Object_Synaptic_Network, PKC, PLA2,
PLCbeta, Gq, MAPK,
Ras, EGFR, Sos,
PLC_g, CaMKII, CaM,
PP1, PP2B, PKA,
AC, CaRegulation | This model is an annotated version of the synaptic signaling network.
The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated.
Bhalla US Biophys J. 2002 Aug;83(2):740-52
Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62 |
inact_cap_entry acting as a Molecule in Synaptic_Network Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | inact_cap_entry | Synaptic_
Network
Accession No. : 16 | CaRegulation
Pathway No. : 86 | 0 | 1000 | No | | This represents the portion of the capacitive-Ca entry channel which is blocked when there is lots of Ca sequestered in the stores. |
inact_cap_entry acting as a Product in a reaction in Synaptic_Network Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | inactivate_cap_
Ca | Synaptic_
Network
Accession No. : 16 | CaRegulation
Pathway No. : 86 | 0
(#^-2 s^-1) | 1
(s^-1) | Not applicable** | - | Substrate
Ca-sequester
Ca-sequester
capacitive_Ca_
entry*
Product
inact_cap_entry
| | The Kd is set to about 3 uM, so that at resting Ca the capacitive Ca entry is almost blocked. A 2nd order response makes the response steep. |
** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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