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Molecule Parameter List for capacitive_Ca_entry*

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
capacitive_Ca_entry* participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000010

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Synaptic_
    Network
  • 16Network
    Shared_Object_Synaptic_Network PKC PLA2 
    PLCbeta Gq MAPK 
    Ras EGFR Sos 
    PLC_g CaMKII CaM 
    PP1 PP2B PKA 
    AC CaRegulation 
    This model is an annotated version of the synaptic signaling network.
    The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated.
    Bhalla US Biophys J. 2002 Aug;83(2):740-52
    Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62

    capacitive_Ca_entry* acting as a Molecule in  
    Synaptic_Network Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    capacitive_Ca_entry*
  • Synaptic_
    Network

    Accession No. : 16
  • CaRegulation
    Pathway No. : 86
    0.011000No
    This mechanism has taken a while to be more tightly confirmed as probably being the TRP channel. In this model the channel is implemented to match experimental observations about capacitive Ca entry. Levels are set by two constraints: the resting Ca levels, and the height of the response to IP3.

    capacitive_Ca_entry* acting as a Substrate in a reaction in  
    Synaptic_Network Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • inactivate_cap_
    Ca
  • Synaptic_
    Network

    Accession No. : 16
  • CaRegulation
    Pathway No. : 86
    0
    (#^-2 s^-1)
    1
    (s^-1)
    Not applicable**-Substrate
    Ca-sequester
    Ca-sequester
  • capacitive_Ca_
    entry*


    Product
    inact_cap_entry
  • The Kd is set to about 3 uM, so that at resting Ca the capacitive Ca entry is almost blocked. A 2nd order response makes the response steep.
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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