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Molecule Parameter List for IP3_3K | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 24 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP3_3K acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP3_3K | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP3-3K
Pathway No. : 124 | 0.3853 | 1000 | No | | from Johanson et al, JBC, 1988, Vol. 263, No.16, pp 7465-7471 this is the predominant isoform in brain ie IP3-3kinaseA: BiochemJ, 1995, 306, 429-435 |
IP3_3K acting as an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | IP3_3K /
ip3-3k
| Osc_Ca_
IP3metabolism
Accession No. : 24 | IP3-3K
Pathway No. : 124 | 1.40001 | 3.0475 | 4 | explicit E-S complex | Substrate
IP3(145)
Product
IP4(1345)
| | from Johanson et al, JBC 263; 1988 Original Vmax scaled up by 50% to obtain value at 37C, as enzyme assay was done at 30C Km increased from 0.2 to 1.4 as per various other reports (Shears Review, BiochemJ 260; 1989) |
IP3_3K acting as a Substrate for an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | tot_CaM_CaMKII /
CaM-CaMK-phos | Osc_Ca_
IP3metabolism
Accession No. : 24 | CaMKII
Pathway No. : 121 | 1.60001 | 0.5 | 4 | explicit E-S complex | Substrate
IP3_3K
Product
IP3_3K*
| | | rates referred from standard CaM-CaMKII phosphorylation rates | | 2 | tot_autonomous_
CaMKII /
CaMK-phos | Osc_Ca_
IP3metabolism
Accession No. : 24 | CaMKII
Pathway No. : 121 | 2.49999 | 0.5 | 4 | explicit E-S complex | Substrate
IP3_3K
Product
IP3_3K*
| | | rates referred from standard CaMKII phosphorylation rates | | 3 | PKC-active /
PKC-phos | Osc_Ca_
IP3metabolism
Accession No. : 24 | PKC
Pathway No. : 123 | 30.0008 | 4 | 4 | explicit E-S complex | Substrate
IP3_3K
Product
IP3_3K*1
| | | rates referred from standard PKC phosphorylation rates |
IP3_3K acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 3K-bind-CaM | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP3-3K
Pathway No. : 124 | 19.2312
(uM^-1 s^-1) | 1
(s^-1) | Kd(bf) = 0.052(uM) | - | Substrate
CaM-Ca4
IP3_3K
Product
IP3_3K_CaM
| | Communi et al, EMBO J 16; 1997 non-phosphorylated 3kinase with low sensitivity to CaM binding (Kd = 52nM) |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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