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Molecule Parameter List for IP4(1345) | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 24 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It differs from the NonOsc_Ca_IP3metabolism network in the CaRegulation module and in InsP3 receptor kinetics. Details of InsP3 receptor kinetics have been adapted from the Othmer-Tang model for oscillatory Ca dynamics. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP4(1345) acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP4(1345) | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP3-3K
Pathway No. : 124 | 1 | 1000 | No | | Inositol(1345)tetrakisphosphate |
IP4(1345) acting as a Substrate for an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | IP_5pase1 /
ip4_5pase | Osc_Ca_
IP3metabolism
Accession No. : 24 | 145_dephos
Pathway No. : 128 | 0.80003 | 0.09 | 4 | explicit E-S complex | Substrate
IP4(1345)
Product
IP3(134)
| | | Ins(1345)P4 5-phosphatase activity of InsP 5-phosphatase1 from Hansen et al, JBC 262; 1987 vmax for IP4 substrate is approx 0.1 times vmax for IP3 | | 2 | 1345_3pase /
ip4_3pase | Osc_Ca_
IP3metabolism
Accession No. : 24 | 1345_dephos
Pathway No. : 131 | 0.400007 | 0.0012 | 4 | explicit E-S complex | Substrate
IP4(1345)
Product
IP3(145)
| | | Ins(1345)P4 3-phosphatase from Nogimori et al, JBC 266; 1991 |
IP4(1345) acting as a Product of an Enzyme in Osc_Ca_IP3metabolism Network
| | Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | | 1 | IP3_3K /
ip3-3k | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP3-3K
Pathway No. : 124 | 1.40001 | 3.0475 | 4 | explicit E-S complex | Substrate
IP3(145)
Product
IP4(1345)
| | | from Johanson et al, JBC 263; 1988 Original Vmax scaled up by 50% to obtain value at 37C, as enzyme assay was done at 30C Km increased from 0.2 to 1.4 as per various other reports (Shears Review, BiochemJ 260; 1989) | | 2 | IP3_3K*1 /
ip3-3k*1 | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP3-3K
Pathway No. : 124 | 1.40004 | 0.76187 | 4.00003 | explicit E-S complex | Substrate
IP3(145)
Product
IP4(1345)
| | | from Sim et al, JBC 265; 1990 | | 3 | IP3_3K* /
ip3-3k* | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP3-3K
Pathway No. : 124 | 1.40001 | 3.0475 | 4 | explicit E-S complex | Substrate
IP3(145)
Product
IP4(1345)
| | | from Communi et al, EMBO J 16; 1997 In absence of CaM binding, activity same as that of non-phosphorylated enzyme | | 4 | IP3_3K_CaM* /
ip3-3k-CaM* | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP3-3K
Pathway No. : 124 | 2.80002 | 45 | 4 | explicit E-S complex | Substrate
IP3(145)
Product
IP4(1345)
| | | from Communi et al, EMBO J 16; 1997 Vmax adjusted to obtain 9-fold greater activity than ip3-3k | | 5 | IP3_3K_CaM /
ip3-3k-CaM | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP3-3K
Pathway No. : 124 | 2.8001 | 10.5 | 4.0001 | explicit E-S complex | Substrate
IP3(145)
Product
IP4(1345)
| | | from Erneux et al, Biochem 214; 1993 2-2.5 fold more active than ip3-3k but Km is doubled, hence Vmax adjusted accordingly. |
IP4(1345) acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
IP4(1345) acting as a Product in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 5kinase | Osc_Ca_
IP3metabolism
Accession No. : 24 | IP4-system
Pathway No. : 129 | 0.0132
(s^-1) | 0
(uM^-1 s^-1) | - | - | Substrate
IP3-56Kcmplx
Product
IP3-56K
IP4(1345)
| | Kf = 0.274 times Vmax of IP3 56-K as product ratio of Ins(1345)P4 : Ins(1346)P4 is 1 : 2.3-5 from Wilson and Majerus, JBC 271; 1996 |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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