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Molecule Parameter List for IP6 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by  color. | | Statistics |
Accession and Pathway Details | |
| Accession Name | Accession No. | Accession Type | Pathway Link | Osc_Ca_
IP3metabolism | 32 | Network |
MIPP, CaMKII, CaM,
PKC, IP3-3K, Gq,
PLCbeta, 134_dephos, 145_dephos,
IP4-system, IHP-system, 1345_dephos,
CaRegulation, Othmer-Tang-model | | This network models an oscillatory calcium response to GPCR mediated PLCbeta activation, alongwith detailed InsP3 metabolism in the neuron. It is similar to the Osc_Ca_IP3metab model (accession 24) except that some enzymes in the InsP3 metabolism network have been modified to have reversible kinetics rather than Michaelis-Menten kinetics. The modified enzymes belong to the groups: IP4-system, IP3-3K, 145_dephos and 134_dephos. Mishra J, Bhalla US. Biophys J. 2002 Sep;83(3):1298-316. |
IP6 acting as a Molecule in Osc_Ca_IP3metabolism Network
| Name | Accession Name | Pathway Name | Initial Conc.
(uM) | Volume
(fL) | Buffered | | IP6 | Osc_Ca_
IP3metabolism
Accession No. : 32 | IHP-system
Pathway No. : 168 | 30.0005 | 1000 | No | | Inositol hexakisphosphate Conc from Voglmaier et al, PNAS 93; 1996 |
IP6 acting as a Substrate for an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | IP6_K2 /
ip6_k2 | Osc_Ca_
IP3metabolism
Accession No. : 32 | IHP-system
Pathway No. : 168 | 2.99999 | 1.633 | 4 | explicit E-S complex | Substrate
IP6
Product
PP-IP5
| | from Saiardi et al, Curr Biol 9; 1999 |
IP6 acting as a Product of an Enzyme in Osc_Ca_IP3metabolism Network
Enzyme Molecule /
Enzyme Activity | Accession Name | Pathway Name | Km (uM) | kcat (s^-1) | Ratio | Enzyme Type | Reagents | DIPP1 /
dipp_ip7 | Osc_Ca_
IP3metabolism
Accession No. : 32 | IHP-system
Pathway No. : 168 | 0.340006 | 5.1 | 4 | explicit E-S complex | Substrate
PP-IP5
Product
IP6
| | from Safrany et al, EMBO J 17(22); 1998 Vmax represents activity of recombinant human protein which is 20-50 fold greater than activity of the purified rat enzyme |
IP6 acting as a Substrate in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| | Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | 1 | ip6_trp | Osc_Ca_
IP3metabolism
Accession No. : 32 | MIPP
Pathway No. : 158 | 0.001
(s^-1) | 1
(s^-1) | Not applicable** | - | Substrate
IP6
Product
IP6_ER
| | | InsP6 ER-cytosol transport. Rate based on cytosolic levels of InsP6. ER-cytosol transport for other inositol phosphates are assigned the same rate as of now, as exact transport rates are not known. | | 2 | IP6-dipp-inhib | Osc_Ca_
IP3metabolism
Accession No. : 32 | IHP-system
Pathway No. : 168 | 1
(uM^-1 s^-1) | 0.2
(s^-1) | Kd(bf) = 0.2(uM) | - | Substrate
DIPP1
IP6
Product
IP6-DIPPcmplx
| | | IC50=0.2uM from Safrany et al, EMBO J 17(22); 1998 | | 3 | IP_4pase-inact | Osc_Ca_
IP3metabolism
Accession No. : 32 | 134_dephos
Pathway No. : 165 | 1
(uM^-1 s^-1) | 19
(s^-1) | Kd(bf) = 19(uM) | - | Substrate
IP6
IP_4pase
Product
IP_4pase_inact
| | | from Norris et al, JBC 269; 1994 | | 4 | IP6-inhib-5pase | Osc_Ca_
IP3metabolism
Accession No. : 32 | 145_dephos
Pathway No. : 166 | 1
(uM^-1 s^-1) | 16
(s^-1) | Kd(bf) = 15.9997(uM) | - | Substrate
IP6
IP_5pase1
Product
IP6-5pase-inhib
| | | from Hoer and Oberdisse, Biochem J 278; 1991: 219-224 | | 5 | IP6cmplx-on | Osc_Ca_
IP3metabolism
Accession No. : 32 | IHP-system
Pathway No. : 168 | 0.0038
(uM^-2 s^-1) | 2.376
(s^-1) | - | - | Substrate
ATP
IP6
IP6-K
Product
IP6-K-complex
| | | from Voglmaier et al, PNAS 93; 1996 Kf calculated from Km for InsP6 and ATP, and Vmax for forward and backward reactions Kb = Vmax of backward reaction | | 6 | IP6-inhib-3pase | Osc_Ca_
IP3metabolism
Accession No. : 32 | 1345_dephos
Pathway No. : 169 | 1
(uM^-1 s^-1) | 0.003
(s^-1) | Kd(bf) = 0.003(uM) | - | Substrate
1345_3pase
IP6
Product
IP6-inhib-3pase-
cmplx
| | | from Hoer and Oberdisse, Biochem J 278; 1991: 219-224 |
IP6 acting as a Product in a reaction in Osc_Ca_IP3metabolism Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | | ip5-kinase-pase | Osc_Ca_
IP3metabolism
Accession No. : 32 | IHP-system
Pathway No. : 168 | 1
(s^-1) | 1.92
(s^-1) | Keq = 1.92(uM) | 0.342sec | Substrate
IP5(13456)
Product
IP6
| | Kf represents InsP5 2-kinase and Kb represents InsP6 2-phosphatase Although InsP5 2-kinases in yeast and plant systems have been characterized (Ives et al, JBC 275; 2000: 36575-83), the mammalian counterpart is still to be worked out. Rates calculated to maintain InsP5 and InsP6 levels |
| Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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