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Molecule Parameter List for CaN | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by  color. | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| Statistics | |||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
| CaN participated as | Molecule | Sum total of | Enzyme | Substrate of an enzyme | Product of an enzyme | Substrate in Reaction | Product in Reaction |
| No. of occurrences | 1 | 0 | 0 | 0 | 0 | 5 | 0 |
Accession and Pathway Details |
| Accession Name | Accession No. | Accession Type | Pathway Link |
| CaMKII | 33 | Network | Shared_Object_CaMKII, CaM, CaMKII, CaN |
| This is a deterministic, point kinetics approximation to the dendritic spine CaMKII model described in William R. Holmes J Comput Neurosci. (2000) 8(1):65-85. Rates are the same but the responses differ somewhat because this model does not include the stochastic and diffusive calculations of the original. | |||
CaN acting as a Molecule in CaMKII Network
| Name | Accession Name | Pathway Name | Initial Conc. (uM) | Volume (fL) | Buffered | |
| CaN | CaMKII Accession No. : 33 | CaN Pathway No. : 175 | 3.6415 | 0.1309 | No | |
| Holmes assumes that there are 286 calcinuerin molecules. | ||||||
CaN acting as a Substrate in a reaction in CaMKII Network
| Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | |
| 1 | CaN-bind-CaM | CaMKII Accession No. : 33 | CaN Pathway No. : 175 | 0.2 (uM^-1 s^-1) | 5000 (s^-1) | Kd(bf) = 25000(uM) | - | Substrate CaM CaN Product CaN-CaM |
| 2 | CaN-bind-CaMCa | CaMKII Accession No. : 33 | CaN Pathway No. : 175 | 5 (uM^-1 s^-1) | 3750 (s^-1) | Kd(bf) = 749.9955(uM) | - | Substrate CaMCa CaN Product CaN-CaMCa |
| 3 | CaN-bind-CaMCa2 | CaMKII Accession No. : 33 | CaN Pathway No. : 175 | 10.0004 (uM^-1 s^-1) | 1250 (s^-1) | Kd(bf) = 124.995(uM) | - | Substrate CaMCa2 CaN Product CaN-CaMCa2 |
| 4 | CaN-bind-CaMCa3 | CaMKII Accession No. : 33 | CaN Pathway No. : 175 | 100.004 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 0.1(uM) | - | Substrate CaMCa3 CaN Product CaN-CaMCa3 |
| 5 | CaN-bind-CaMCa4 | CaMKII Accession No. : 33 | CaN Pathway No. : 175 | 100.004 (uM^-1 s^-1) | 0.6 (s^-1) | Kd(bf) = 0.006(uM) | - | Substrate CaMCa4 CaN Product CaN-CaMCa4 |