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Molecule Parameter List for CaMKII-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-PSD participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1102221

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    weak_coupling
  • 65Network
    Shared_Object_AMPAR_CaMKII_weak_coupling CaMKII CaM 
    PP1 PP2B PP1_PSD 
    AMPAR PKA AC 
    AMPAR_memb PP1_CaMKII_PSD CaMKII_PSD 
    This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.

    CaMKII-PSD acting as a Molecule in  
    AMPAR_CaMKII_weak_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaMKII-PSD
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • CaMKII_PSD
    Pathway No. : 292
    00.01No

    CaMKII-PSD acting as a Summed Molecule in  
    AMPAR_CaMKII_weak_coupling Network
    Accession NamePathway NameTargetInput
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • CaMKII_PSD
    Pathway No. : 292
    tot_CaMKII_PSDactCaMKII-PSD
    CaMKII-PSD
  • CaMKII-thr305-PS
    D


  • CaMKII-PSD acting as a Substrate for an Enzyme in  
    AMPAR_CaMKII_weak_coupling Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1
  • tot-CaM-CaMKII-P
    SD
      /
    CaM_act_autoph
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • CaMKII_PSD
    Pathway No. : 292
    320.00224explicit E-S complexSubstrate
    CaMKII-PSD

    Product
  • CaMKII-thr286-PS
    D

  • 2tot-auto-PSD  /
    auton-autoph
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • CaMKII_PSD
    Pathway No. : 292
    500.00524explicit E-S complexSubstrate
    CaMKII-PSD

    Product
  • CaMKII-thr286-PS
    D


  • CaMKII-PSD acting as a Product of an Enzyme in  
    AMPAR_CaMKII_weak_coupling Network
     Enzyme Molecule /
    Enzyme Activity
    Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1
  • PP1-active_
    CaMKII_PSD
      /
    Deph-thr286b
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP1_CaMKII_PSD
    Pathway No. : 291
    2.000010.24explicit E-S complexSubstrate
  • CaMKII-thr286-PS
    D


    Product
    CaMKII-PSD
  • 2
  • PP1-active_
    CaMKII_PSD
      /
    Deph-thr305a
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • PP1_CaMKII_PSD
    Pathway No. : 291
    2.000010.24explicit E-S complexSubstrate
  • CaMKII-thr305-PS
    D


    Product
    CaMKII-PSD

  • CaMKII-PSD acting as a Substrate in a reaction in  
    AMPAR_CaMKII_weak_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1
  • CaMKII-bind-CaM-
    PSD
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • CaMKII_PSD
    Pathway No. : 292
    49.9998
    (uM^-1 s^-1)
    0
    (s^-1)
    --Substrate
    CaM-Ca4-PSD
    CaMKII-PSD

    Product
    CaMKII-CaM-PSD
    2back_1
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • CaMKII_PSD
    Pathway No. : 292
    0.3
    (s^-1)
    0
    (#^-1 s^-1)
    Not applicable**-Substrate
    CaMKII-PSD

    Product
    CaMKII
    NMDAR
      Rates set by the translocation experiments of Shen and Meyer, Science 1999. Note that this reaction also incorporates a translocation between compartments of different volumes.
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

    CaMKII-PSD acting as a Product in a reaction in  
    AMPAR_CaMKII_weak_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaMKII-diss-CaM
  • AMPAR_CaMKII_
    weak_coupling

    Accession No. : 65
  • CaMKII_PSD
    Pathway No. : 292
    5
    (s^-1)
    0
    (uM^-1 s^-1)
    --Substrate
    CaMKII-CaM-PSD

    Product
    CaM-Ca4-PSD
    CaMKII-PSD



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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