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Molecule Parameter List for CaMKII-CaM-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color.

Statistics

CaMKII-CaM-PSD participated as	Molecule	Sum total of	Enzyme	Substrate of an enzyme	Product of an enzyme	Substrate in Reaction	Product in Reaction
No. of occurrences	1	2	0	2	1	1	2

Accession and Pathway Details

Accession Name	Accession No.	Accession Type	Pathway Link
AMPAR_CaMKII_ weak_coupling	65	Network	Shared_Object_AMPAR_CaMKII_weak_coupling,  CaMKII,  CaM,   PP1,  PP2B,  PP1_PSD,   AMPAR,  PKA,  AC,   AMPAR_memb,  PP1_CaMKII_PSD,  CaMKII_PSD
This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.

CaMKII-CaM-PSD acting as a Molecule in  AMPAR_CaMKII_weak_coupling Network

Name	Accession Name	Pathway Name	Initial Conc. (uM)	Volume (fL)	Buffered
CaMKII-CaM-PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	0	0.01	No

CaMKII-CaM-PSD acting as a Summed Molecule in  AMPAR_CaMKII_weak_coupling Network

	Accession Nane	Pathway Name	Target	Input
1	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	tot-CaM-CaMKII-PSD	CaMKII-thr286-Ca M-PSD CaMKII-CaM-PSD
2	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	actCaMKII-PSD	CaMKII-thr286-Ca M-PSD CaMKII-CaM-PSD tot-auto-PSD

CaMKII-CaM-PSD acting as a Substrate for an Enzyme in  AMPAR_CaMKII_weak_coupling Network

	Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
1	tot-CaM-CaMKII-P SD  / CaM-act-286-PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	319.996	0.5	4	explicit E-S complex	Substrate CaMKII-CaM-PSD Product CaMKII-thr286-Ca M-PSD
2	tot-auto-PSD  / auton-286-PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	500.002	0.5	4	explicit E-S complex	Substrate CaMKII-CaM-PSD Product CaMKII-thr286-Ca M-PSD

CaMKII-CaM-PSD acting as a Product of an Enzyme in  AMPAR_CaMKII_weak_coupling Network

Enzyme Molecule / Enzyme Activity	Accession Name	Pathway Name	Km (uM)	kcat (s^-1)	Ratio	Enzyme Type	Reagents
PP1-active_ CaMKII_PSD  / Deph-thr286	AMPAR_CaMKII_ weak_coupling Accession No. : 65	PP1_CaMKII_PSD Pathway No. : 291	2.00001	0.2	4	explicit E-S complex	Substrate CaMKII-thr286-Ca M-PSD Product CaMKII-CaM-PSD

CaMKII-CaM-PSD acting as a Substrate in a reaction in  AMPAR_CaMKII_weak_coupling Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
CaMKII-diss-CaM	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	5 (s^-1)	0 (uM^-1 s^-1)	-	-	Substrate CaMKII-CaM-PSD Product CaM-Ca4-PSD CaMKII-PSD

CaMKII-CaM-PSD acting as a Product in a reaction in  AMPAR_CaMKII_weak_coupling Network

Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.

	Name	Accession Name	Pathway Name	Kf	Kb	Kd	tau	Reagents
1	CaMKII-bind-CaM- PSD	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	49.9998 (uM^-1 s^-1)	0 (s^-1)	-	-	Substrate CaM-Ca4-PSD CaMKII-PSD Product CaMKII-CaM-PSD
2	transloc_1	AMPAR_CaMKII_ weak_coupling Accession No. : 65	CaMKII_PSD Pathway No. : 292	0 (#^-1 s^-1)	0 (s^-1)	Not applicable**	-	Substrate CaMKII-CaM NMDAR Product CaMKII-CaM-PSD
	Rates to match curve in fig2 from Shen and Meyer, Science 284:162-166(1999), calculated for 6:1 alpha:beta CaMKII heterodimers Note that this reaction also incorporates a translocation between compartments of different volumes.

** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration