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Molecule Parameter List for CaMKII-thr286-CaM-PSD

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaMKII-thr286-CaM-PSD participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1301202

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • AMPAR_CaMKII_
    weak_coupling
    		• 65Network
    Shared_Object_AMPAR_CaMKII_weak_coupling,  CaMKII,  CaM,  
    PP1,  PP2B,  PP1_PSD,  
    AMPAR,  PKA,  AC,  
    AMPAR_memb,  PP1_CaMKII_PSD,  CaMKII_PSD 
    This is a model of weak coupling between the AMPAR traffikcing bistability, and the CaMKII autophosphorylation bistability. In this model, there are three stable states: Both off, AMPAR on, or both on. The fourth possible state: CaMKII on but AMPAR off, is not truly stable, since over the course of hours the AMPAR also turns on.

    CaMKII-thr286-CaM-PSD acting as a Molecule in      AMPAR_CaMKII_weak_coupling Network
    NameAccession NamePathway NameInitial Conc.
    (uM)    		Volume
    (fL)    		Buffered
    CaMKII-thr286-CaM-PSD
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII_PSD
    Pathway No. : 292    		00.01No

    CaMKII-thr286-CaM-PSD acting as a Summed Molecule in      AMPAR_CaMKII_weak_coupling Network
     Accession NanePathway NameTargetInput
    1
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII_PSD
    Pathway No. : 292    		tot-CaM-CaMKII-PSD
  • CaMKII-thr286-Ca
    M-PSD
    CaMKII-CaM-PSD
    • 2
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII_PSD
    Pathway No. : 292    		actCaMKII-PSD
  • CaMKII-thr286-Ca
    M-PSD
    CaMKII-CaM-PSD
    tot-auto-PSD
    • 3
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII_PSD
    Pathway No. : 292    		286P-PSD
  • CaMKII-thr286-Ca
    M-PSD
  • CaMKII-thr286-PS
    D

    • CaMKII-thr286-CaM-PSD acting as a Substrate for an Enzyme in      AMPAR_CaMKII_weak_coupling Network
    Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
  • PP1-active_
    CaMKII_PSD      /
    Deph-thr286
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• PP1_CaMKII_PSD
    Pathway No. : 291    		2.000010.24explicit E-S complexSubstrate
  • CaMKII-thr286-Ca
    M-PSD

    Product
    CaMKII-CaM-PSD

    • CaMKII-thr286-CaM-PSD acting as a Product of an Enzyme in      AMPAR_CaMKII_weak_coupling Network
     Enzyme Molecule /
    Enzyme Activity    		Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
    1
  • tot-CaM-CaMKII-P
    SD      /
    CaM-act-286-PSD
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII_PSD
    Pathway No. : 292    		319.9960.54explicit E-S complexSubstrate
    CaMKII-CaM-PSD

    Product
  • CaMKII-thr286-Ca
    M-PSD
    • 2tot-auto-PSD  /
    auton-286-PSD
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII_PSD
    Pathway No. : 292    		500.0020.54explicit E-S complexSubstrate
    CaMKII-CaM-PSD

    Product
  • CaMKII-thr286-Ca
    M-PSD

    • CaMKII-thr286-CaM-PSD acting as a Product in a reaction in      AMPAR_CaMKII_weak_coupling Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
     NameAccession NamePathway NameKfKbKdtauReagents
    1
  • CaMKII-thr286-bi
    nd-CaM-PSD
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII_PSD
    Pathway No. : 292    		1000.02
    (uM^-1 s^-1)    		0.1
    (s^-1)    		Kd(bf) = 0.0001(uM)-Substrate
    CaM-Ca4-PSD
  • CaMKII-thr286-PS
    D

    Product
  • CaMKII-thr286-Ca
    M-PSD
    •   Same values as for the main compartment Can the main compartment pool of Ca/CaM be used?
    2transloc_2
  • AMPAR_CaMKII_
    weak_coupling
    Accession No. : 65
    		• CaMKII_PSD
    Pathway No. : 292    		0
    (#^-1 s^-1)    		0
    (s^-1)    		Not applicable**-Substrate
  • CaMKII-thr286*-C
    aM
    NMDAR

    Product
  • CaMKII-thr286-Ca
    M-PSD
    •   Same as for transloc_1
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration


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