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Molecule Parameter List for CaM-Ca4 | The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network. The text color of a molecule is highlighted by color. | Statistics | Accession and Pathway Details | |
Accession Name | Accession No. | Accession Type | Pathway Link | Ajay_Bhalla_ 2007_ReacDiff3 | 84 | Network | Shared_Object_Ajay_Bhalla_2007_ReacDiff3, PKC, PLA2, MAPK, PLA2, Ras, CaM, chain, kinetics, PKC, MAPK, Ras, CaM, kinetics[1], PKC, PLA2, MAPK, Ras, CaM, kinetics[2], PKC, PLA2, MAPK, Ras, CaM, kinetics[3], PKC, PLA2, MAPK, Ras, CaM, kinetics[4], PKC, PLA2, MAPK, Ras, CaM, kinetics[5], PKC, PLA2, MAPK, Ras, MAPK, CaM, kinetics[6], PKC, PLA2, MAPK, Ras, CaM, kinetics[7], PKC, PLA2, MAPK, Ras, CaM, PKC, kinetics[8], PLA2, MAPK, Ras, CaM, kinetics[9], PKC, PLA2, MAPK, Ras, CaM, kinetics[10], PKC, PLA2, MAPK, Ras, CaM, kinetics[11], PKC, PLA2, MAPK, Ras, CaM, kinetics[12], PKC, PLA2, Ras, CaM, kinetics[13], PKC, PLA2, MAPK, Ras, CaM, kinetics[14], PKC, PLA2, MAPK, Ras, CaM, kinetics[15], PKC, PLA2, MAPK, Ras, kinetics[16], CaM, PKC, PLA2, MAPK, Ras, CaM, kinetics[17], PKC, PLA2, MAPK, Ras, CaM, kinetics[18], PKC, PLA2, MAPK, Ras, CaM, kinetics[19], PKC, PLA2, MAPK, Ras, CaM, kinetics[20], PKC, PLA2, MAPK, Ras, CaM, kinetics[21], PKC, PLA2, MAPK, Ras, CaM, kinetics[22], PKC, PLA2, MAPK, Ras, CaM, kinetics[23], PKC, PLA2, MAPK, Ras, CaM | This is a 25-compartment reaction-diffusion version of the Ajay_Bhalla_2007_bistable model. The original single-compartment model is repeated 25 times.
In addition, a subset (33 out of 50) molecules can diffuse between compartments. Diffusion is implemented as a reaction between corresponding molecules in neighboring compartments. Here D = 1e-13 m^2/sec (i.e., 0.1 micron^2/sec ) so the kf and kb of this reaction for these 10 micron compartments are both 0.001/sec.
The basal calcium level in this model is held at 95 nM which is rather close to threshold for the flip to the active state. This is necessary to sustain active propagation of activation.
The stimulus file bis6-propgn_D1e-13_FigEF which was used for the model to replicate Figure 4E and 4F from the paper. |
CaM-Ca4 acting as a Molecule in Ajay_Bhalla_2007_ReacDiff3 Network
CaM-Ca4 acting as a Substrate in a reaction in Ajay_Bhalla_2007_ReacDiff3 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | 1 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 923 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 2 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 3 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 929 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 4 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 5 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 935 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 6 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 7 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 959 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 8 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 941 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 9 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 10 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 947 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 11 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 12 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 953 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 13 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 14 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 15 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 966 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 16 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 17 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 972 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 18 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 19 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 978 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 20 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 21 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 984 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 22 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 23 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 990 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 24 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 25 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 996 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 26 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 27 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 1001 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 28 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 29 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 1007 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 30 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 31 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 1013 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 32 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 33 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 1019 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 34 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 35 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 1025 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 36 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 37 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 1031 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 38 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 39 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 1037 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 40 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 41 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 1043 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 42 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 43 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 1049 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 44 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 45 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 1055 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 46 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 47 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 1061 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. | 48 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 49 | CaM-bind-GEF | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Ras Pathway No. : 1067 | 199.995 (uM^-1 s^-1) | 1 (s^-1) | Kd(bf) = 0.005(uM) | - | Substrate CaM-Ca4 inact-GEF
Product CaM-GEF
| | We have no numbers for this. It is probably between the two extremes represented by the CaMKII phosph states, and I have used guesses based on this. kf=1e-4 kb=1 The reaction is based on Farnsworth et al Nature 376 524-527 1995 28 Feb 2006: Increased affinity 36-fold to account for Ca input to MAPK cascade, possibly folding in other pathway inputs. 21 April 2006: Altered affinity to same level as pkm_mapk21.g model to prevent spontaneous turnon. Kf = 200, Kb = 1. |
CaM-Ca4 acting as a Product in a reaction in Ajay_Bhalla_2007_ReacDiff3 Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated.
Kd for higher order reaction are not consider. |
| Name | Accession Name | Pathway Name | Kf | Kb | Kd | tau | Reagents | 1 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 924 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 2 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 3 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 930 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 4 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 5 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 936 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 6 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 7 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 942 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 8 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 9 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 948 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 10 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 11 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 954 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 12 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 13 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 961 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 14 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 15 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 967 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 16 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 17 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 973 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 18 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 19 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 979 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 20 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 21 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 985 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 22 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 23 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 991 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 24 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 25 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 997 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 26 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 27 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 1002 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 28 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 29 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 1008 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 30 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 31 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 1014 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 32 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 33 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 1021 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 34 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 35 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 1026 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 36 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 37 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 1032 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 38 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 39 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 1038 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 40 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 41 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 1044 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 42 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 43 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 1050 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 44 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 45 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 1056 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 46 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 47 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 1062 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 | 48 | diff | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | Shared_Object_ Ajay_Bhalla_ 2007_ReacDiff3 Pathway No. : 918 | 0.001 (s^-1) | 0.001 (s^-1) | Keq = 1(uM) | 500sec | Substrate CaM-Ca4
Product CaM-Ca4
| 49 | CaM-Ca3-bind-Ca | Ajay_Bhalla_ 2007_ReacDiff3 Accession No. : 84 | CaM Pathway No. : 1068 | 0.465 (uM^-1 s^-1) | 10 (s^-1) | Kd(bf) = 21.5051(uM) | - | Substrate Ca CaM-Ca3
Product CaM-Ca4
| | Use K3 = 21.5 uM here from Stemmer and Klee table 3. kb/kf =21.5 * 6e5 so kf = 7.75e-7, kb = 10 |
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