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Accession Type:
Network
MAPK-bistability
-fig1c
Shared_Object_
MAPK-bistability
-fig1c
Sos
PKC
MAPK
PLA2
 Molecule
 Enzyme
 Reaction
Ras
PDGFR

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Parameters for PLA2 (Pathway Number 183)

Pathway Layout

Pathway Basic Parameters

Pathway NamePLA2
Pathway Entry Number 183
Accession Number 35
Accession Name MAPK-bistability-fig1c
Species Generic mammalian
Tissue NIH 3T3 Expression
CellCompartmentSurface - Nucleus
Related Pathways 3, 21, 36, 57, 62, 72, 208, 314, 331, 349, 365, 920, 922, 933, 939, 945, 951, 957, 964, 970, 976, 982, 988, 994, 1000, 1005, 1011, 1017, 1023, 1029, 1035, 1041, 1047, 1053, 1059, 1065
Notes Main source of data: Leslie and Channon BBA 1045 (1990) pp 261-270. Fig 6 is Ca curve. Fig 4a is PIP2 curve. Fig 4b is DAG curve. Also see Wijkander and Sundler JBC 202 (1991) pp873-880; Diez and Mong JBC 265(24) p14654; Leslie JBC 266(17) (1991) pp11366-11371 Many inputs activate PLA2. In this model I simply take each combination of stimuli as binding to PLA2 to give a unique enzymatic activity. The Km and Vmax of these active complexes is scaled according to the relative activation reported in the papers above.

Statistics

8
5
7

Conversion format

This pathway is part of accession 35 and is completely specified in the file acc35.g.
There is no separate files for just this pathway.
FormatFile
Native Format (GENESIS format)    acc35.g   
GENESIS Format (Annotated version)    Anno_acc35.g   
MATLAB format    acc35.m   
SBML format    acc35.xml   


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Database compilation and code copyright (C) 2005, Upinder S. Bhalla and NCBS/TIFR
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