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Molecule Parameter List for PLC-Ca

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
PLC-Ca participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1010012

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
fig2_egfr1Network
Shared_Object_fig2_egfr PKC PLA2 
PLCbeta Gq MAPK 
Ras EGFR Sos 
PLC_g CaRegulation 
This network was used to generate figure 2 in Bhalla US and Iyengar R. Science (1999) 283(5400):381-7. It consists of the MAPK cascade in a feedback loop with PKC, and receives input from the EGFR in the synapse.
Demonstration script files for generating the figures in the paper, including figure 2, are available here.

PLC-Ca acting as a Molecule in  
fig2_egfr Network
NameAccession NamePathway NameInitial Conc.
(uM)
Volume
(fL)
Buffered
PLC-Cafig2_egfr
Accession No. : 1
PLCbeta
Pathway No. : 4
01000No

PLC-Ca acting as an Enzyme in  
fig2_egfr Network
Enzyme Molecule /
Enzyme Activity
Accession NamePathway NameKm (uM)kcat (s^-1)RatioEnzyme TypeReagents
PLC-Ca /
PLC-Ca
fig2_egfr
Accession No. : 1
PLCbeta
Pathway No. : 4
19.8413104explicit E-S complexSubstrate
PIP2

Product
DAG
IP3

PLC-Ca acting as a Substrate in a reaction in  
fig2_egfr Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
NameAccession NamePathway NameKfKbKdtauReagents
Act-PLC-by-Gqfig2_egfr
Accession No. : 1
PLCbeta
Pathway No. : 4
25.2
(uM^-1 s^-1)
1
(s^-1)
Kd(bf) = 0.0397(uM)-Substrate
G*GTP
PLC-Ca

Product
PLC-Ca-Gq

PLC-Ca acting as a Product in a reaction in  
fig2_egfr Network
Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
 NameAccession NamePathway NameKfKbKdtauReagents
1Act-PLC-Cafig2_egfr
Accession No. : 1
PLCbeta
Pathway No. : 4
3
(uM^-1 s^-1)
1
(s^-1)
Kd(bf) = 0.3333(uM)-Substrate
Ca
PLC

Product
PLC-Ca
2Inact-PLC-Gqfig2_egfr
Accession No. : 1
PLCbeta
Pathway No. : 4
0.0133
(s^-1)
0
(uM^-1 s^-1)
--Substrate
PLC-Ca-Gq

Product
G*GDP
PLC-Ca



Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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