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Molecule Parameter List for CaTransp-2Ca

The statistics table lists the distribution of a molecule acting either as a substrate, product, enzyme or as a molecule within the network.
The text color of a molecule is highlighted by color.
Statistics
CaTransp-2Ca participated asMoleculeSum total ofEnzymeSubstrate of an enzymeProduct of an enzymeSubstrate in ReactionProduct in Reaction
No. of occurrences1000011

Accession and Pathway Details
Accession NameAccession No.Accession TypePathway Link
  • Synaptic_
    Network
  • 16Network
    Shared_Object_Synaptic_Network PKC PLA2 
    PLCbeta Gq MAPK 
    Ras EGFR Sos 
    PLC_g CaMKII CaM 
    PP1 PP2B PKA 
    AC CaRegulation 
    This model is an annotated version of the synaptic signaling network.
    The primary reference is Bhalla US and Iyengar R. Science (1999) 283(5400):381-7 but several of the model pathways have been updated.
    Bhalla US Biophys J. 2002 Aug;83(2):740-52
    Bhalla US J Comput Neurosci. 2002 Jul-Aug;13(1):49-62

    CaTransp-2Ca acting as a Molecule in  
    Synaptic_Network Network
    NameAccession NamePathway NameInitial Conc.
    (uM)
    Volume
    (fL)
    Buffered
    CaTransp-2Ca
  • Synaptic_
    Network

    Accession No. : 16
  • CaRegulation
    Pathway No. : 86
    01000No
    This is equivalent to the enzyme-substrate complex. 2 Ca are bound to the transporter. The ATP is ignored.

    CaTransp-2Ca acting as a Substrate in a reaction in  
    Synaptic_Network Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
    CaTraspATPase
  • Synaptic_
    Network

    Accession No. : 16
  • CaRegulation
    Pathway No. : 86
    25
    (s^-1)
    0
    (#^-2 s^-1)
    Not applicable**-Substrate
    CaTransp-2Ca

    Product
    Ca-sequester
    Ca-sequester
    CaTransp
    kCa3 = 2 * Ca transporter rate since each step has 2 Ca++. = 0.5 uM/sec from Lauffenburger and Linderman 1993 Receptors pg 200. The amount of the activated transporter is about 0.01 uM = 6e3 #. from runs. So 0.01uM * kf * 2 = 0.5 uM/sec (no back reaction) so kf = 25, kb = 0 Alternatively, 6e3 * kf = 0.25 * 6e5, giving the same kf
    ** This is a trasport reation between compartments of different volumes. Therefore Kd is not applicable. Please Note Kf, Kb units are in number of molecules instead of concentration

    CaTransp-2Ca acting as a Product in a reaction in  
    Synaptic_Network Network
    Kd is calculated only for second order reactions, like nA+nB <->nC or nA<->nC+nD, where n is number and A,B,C,D are molecules, where as for first order reactions Keq is calculated. Kd for higher order reaction are not consider.
    NameAccession NamePathway NameKfKbKdtauReagents
  • Ca-bind-to-Trans
    p
  • Synaptic_
    Network

    Accession No. : 16
  • CaRegulation
    Pathway No. : 86
    3600
    (uM^-2 s^-1)
    144
    (s^-1)
    Kd(bf) = 0.04(uM)-Substrate
    CaTransp
    Ca_intracell
    Ca_intracell

    Product
    CaTransp-2Ca
    Rates from Lauffenberger and Linderman 1993 Receptors pg 200. Kd = KCa2 = 0.2 uM.



    Database compilation and code copyright (C) 2022, Upinder S. Bhalla and NCBS/TIFR
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